BIOPEP-UWM: Report

ID 7582
Name ACE inhibitor
sequence
RP
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
2
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 271.3153 Monoisotopic mass 271.1640
EC50 :
180.00 µM


Bibliographic data:
Authors
Cheung H.-S., Wang F.-L., Ondetti M. A., Sabo E. F., Cushman D. W.
Title
Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. J. Biol. Chem., 255, 401-407
Year Source
1980 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: C1C[C@H](N(C1)C(=O)[C@H](CCCN=C(N)N)N)C(=O)O

InChI=1S/C11H21N5O3/c12-7(3-1-5-15-11(13)14)9(17)16-6-2-4-8(16)10(18)19/h7-8H,1-6,12H2,(H,18,19)(H4,13,14,15)/t7-,8-/m0/s1

InChIKey: LQJAALCCPOTJGB-YUMQZZPRSA-N


Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M02-001

Inhibitor of the neurolysin (EC 3.4.24.16) (MEROPS ID: M03.002) according to the BIOPEP-UWM database of bioactive peptides; the BRENDA database
Antinociceptive activity according to the ChEMBL database; the PubChem database
Affinity to neurotensin receptor according to the ChEMBL database; the PubChem database
Antiviral peptide according to the AVPdb database
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP database of bioactive peptides (ID 8518)

Bitter peptide according to the BIOPEP database of sensory peptides and amino acids (ID 11)
Salty taste enhancing peptide according to the BIOPEP database of sensory peptides and amino acids (ID 419)


Database reference:
ACToR: ID 2418-69-1

AHTPDB: ID 1120; 1390; 1470; 1502; 2793; 3054; 3056; 3083; 3179; 3221; 3533; 3583; 3789; 4021; 4442; 4495; 4676; 5423; 5452; 5641; 5676; 6114; 6568

AVPdb: ID AVP1054

BIOPEP database of bioactive peptides: ID 8518; 10116; 10171

BIOPEP database of sensory peptides and amino acids: ID 11; 419

BRENDA: Ligand Arg-Pro

ChEMBL: ID CHEMBL48223

ChemIDplus: ID 002418691

ChemSpider: ID 133095

EROP-Moscow: ID E10402

PubChem: ID 151003

SATPdb: ID satpdb23927

ZINC: ID ZINC04899739