BIOPEP-UWM: Report

ID 7589
Name ACE inhibitor
sequence
YA
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
2
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 252.2658 Monoisotopic mass 252.1106
EC50 :
460.00 µM


Bibliographic data:
Authors
Cushman D. W.
Title
Angiotensin converting enzyme inhibitors: Evolution of a new class of antihypertensive drugs (page 19). in: Horovitz Z. P. (Ed.) (1981), Mechanisms of action and clinical implications, Urban & Schwarzenberg.
Year Source
1981 book


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(C)C(=O)O

InChI=1S/C12H16N2O4/c1-7(12(17)18)14-11(16)10(13)6-8-2-4-9(15)5-3-8/h2-5,7,10,15H,6,13H2,1H3,(H,14,16)(H,17,18)/t7-,10-/m0/s1

InChIKey: NLKUJNGEGZDXGO-XVKPBYJWSA-N


Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M02-001


Peptide found in cod protein hydrolysates:

Geirsdóttir M., 2009, Isolation, purification and investigation of peptides from fish proteins with blood pressure decreasing properties. Report from the project funded by the AVS research fund under the Ministry of Fisheries in Iceland (project no. R-047-07). Matís Report 36-09, Matís, Reykjavik, Iceland, http://www.avs.is/media/avs/36-09_skyrsla_einangrun_peptida.pdf


Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID A01.007) according to the BIOPEP-UWM database of bioactive peptides (ID 9433)
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8932)
Inhibitor of Alanine carboxypeptidase (EC 3.4.17.6) (MEROPS ID: M9E.002) according to the BRENDA database
Inhibitor of Tubulin-tyrosine ligase (EC 6.3.2.25) according to the BRENDA database


Database reference:
AHTPDB: ID 3228, 3547, 3831, 4052, 4433, 4537, 4681, 6575

BindingDB: ID 50169129

BioCyc: ID CPD-20389

BioPepDB: ID biopep01546

BIOPEP-UWM database of bioactive peptides: ID 8932, 9433

BRENDA: Ligand Tyr-Ala

ChEBI: ID 74879

ChEMBL: ID CHEMBL316103

ChemDB: ID 192304, 192311

ChemSpider: ID 4593326

J-GLOBAL: ID 200907038195226293

Metabolights: ID MTBLC74879

Nikkaji: ID J150.477K

PubChem: CID 7020632

SATPdb: ID satpdb10716

SDBS: ID 9370

SureChEMBL: ID SCHEMBL238988

ZINC: ID ZINC000002566273