BIOPEP-UWM: Report

ID 7603
Name ACE inhibitor
sequence
GR
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
2
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 231.2516 Monoisotopic mass 231.1328
EC50 :
3200.00 µM


Bibliographic data:
Authors
Cheung H.-S., Wang F.-L., Ondetti M. A., Sabo E. F., Cushman D. W.
Title
Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. J. Biol. Chem., 255, 401-407, 1980
Year Source
1980 Journal


Additional information:

BIOPEP-UWM database of bioactive peptides


SMILES: C(C[C@@H](C(=O)O)NC(=O)CN)CNC(=N)N

InChI=1S/C8H17N5O3/c9-4-6(14)13-5(7(15)16)2-1-3-12-8(10)11/h5H,1-4,9H2,(H,13,14)(H,15,16)(H4,10,11,12)/t5-/m0/s1

InChIKey: JLXVRFDTDUGQEE-YFKPBYRVSA-N


Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M02-001

Another value of the peptide IC50(EC50)=162.2uM.

Sentandreu M. A., Toldra F., 2007. Evaluation of ACE inhibitory activity of dipeptides generated by the action of porcine muscle dipeptidyl peptidases. Food Chemistry, 102, 2, 511-515.


Bitter peptide according to BIOPEP-UWM database of sensory peptides and amino acids


Database reference:
ACToR: ID 18635-55-7

AHTPDB: ID 1427; 3000; 3042; 3085; 3114; 3236; 3491; 3807; 3933; 4416; 4513; 4668; 5152; 5421; 5434; 6109; 6589

BindingDB: ID 50407457

BioPepDB: ID biopep00409

BIOPEP-UWM database of sensory peptides and amino acids: ID 16

BRENDA: Ligand Gly-Arg

ChEBI: ID 73860

ChEMBL: ID CHEMBL96806

ChemSpider: ID 4932140

EROP-Moscow: ID E10383

J-GLOBAL: ID 200907022189681376

Metabolights: ID MTBLC73860

Nikkaji: ID J1.481.855C

PubChem: CID 6426706

SATPdb: ID satpdb16592

SureChEMBL: ID SCHEMBL187696

ZINC: ID ZINC01576211