BIOPEP-UWM: Report

ID 7692
Name ACE inhibitor
sequence
KF
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
2
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 293.3605 Monoisotopic mass 293.1734
EC50 :
28.30 µM


Bibliographic data:
Authors
Meisel H., Walsh D. J., Murray B., FitzGerald R. J.
Title
ACE inhibitory peptides. in: Nutraceutical proteins and peptides in health and disease. Mine Y., Shahidi F. (Eds.), CRC Taylor & Francis Group, Boca Raton, London, New York, 269-315.
Year Source
2006 book


Additional information:

BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)O

InChI=1S/C15H23N3O3/c16-9-5-4-8-12(17)14(19)18-13(15(20)21)10-11-6-2-1-3-7-11/h1-3,6-7,12-13H,4-5,8-10,16-17H2,(H,18,19)(H,20,21)/t12-,13-/m0/s1

InChIKey: QCZYYEFXOBKCNQ-STQMWFEESA-N


Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M02-001


Another value of peptide EC50 = 7.23

Li H., Aluko R. E., 2010, Identification and inhibitory properties of multifunctional peptides from pea protein hydrolysate. J. Agric. Food Chem., 58, 11471-11476

Found in pea protein hydrolysate

Li H., Aluko R. E., 2010, Identification and inhibitory properties of multifunctional peptides from pea protein hydrolysate. J. Agric. Food Chem., 58, 11471-11476

Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID A01.007) according to the BIOPEP-UWM database of bioactive peptides (ID 8248)
Inhibitor of calmodulin-dependent phosphodiesterase 1 (CaMPDE) (EC 3.1.4.17) according to the BIOPEP-UWM database of bioactive peptides (ID 8249)
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8809)
Inhibitor of Leucyltransferase (EC 2.3.2.6) according to the BRENDA database

Bitter peptide according to BIOPEP-UWM database of sensory peptides and amino acids


Database reference:
ACToR: ID 6235-35-4

AHTPDB: ID 1447; 1456; 2673; 2774; 2850; 3010; 3040; 3269; 3318; 3433; 3507; 3966; 4737; 5158; 5424;
6259; 6678; 6875

BindingDB: ID 50049726

BioPepDB: ID biopep00670

BIOPEP-UWM database of bioactive peptides: ID 8248; 8249; 8809

BIOPEP-UWM database of sensory peptides and amino acids: ID 56

BRENDA: Ligand Lys-Phe

ChEBI: ID 73605

ChEMBL: ID CHEMBL3321994

ChemIdPlus: ID 6235-35-4

ChemSpider: ID 133442

EROP-Moscow: ID E10439

J-Global: ID 200907094343429899

Metabolights: ID MTBLC73605

Nikkaji: ID J231.730C

PubChem: CID 151410

SATPdb: ID satpdb29026

SureChEMBL: ID SCHEMBL1374146

ZINC: ID ZINC02522657