BIOPEP-UWM: Report

ID 7772
Name ACTH receptor antagonist
sequence
GKVLKKRR
Function:
Binds to the ACTH receptor on mouse splenocytes and macrophages with high affinity and specificity.
 
Number of residues
8
Activity code
bin
Activity :
binding
Chemical mass 984.2401 Monoisotopic mass 983.6698
EC50 :
0.00 µM


Bibliographic data:
Authors
Navolostkaya E. V., Kovalitskaya Y. A., Sadovnikov V. B., Zolotarev Y. A., Kolobov A. A., Yurovsky V. V., Lipkin V. M.
Title
Synthetic ACTH-like peptide GKVLKKRR, corresponding to the fragment 81-88 of human pro-interleukin-1 alpha, acts as an anatgonist of ACTH receptor. Int. J. Pept. Res. Ther., 2008, 14, 10-15
Year Source
2008 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@@](CCCNC(N)=N)(NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]([H])(CCCCN)NC(=O)[C@]([H])(CCCCN)NC(=O)[C@]([H])(CC(C)C)NC(=O)[C@@]([H])(NC(=O)[C@]([H])(CCCCN)NC(=O)CN)C(C)C)C(O)=O

InChI=1S/C43H85N17O9/c1-25(2)23-32(59-40(67)34(26(3)4)60-38(65)27(13-5-8-18-44)54-33(61)24-47)39(66)57-29(15-7-10-20-46)36(63)55-28(14-6-9-19-45)35(62)56-30(16-11-21-52-42(48)49)37(64)58-31(41(68)69)17-12-22-53-43(50)51/h25-32,34H,5-24,44-47H2,1-4H3,(H,54,61)(H,55,63)(H,56,62)(H,57,66)(H,58,64)(H,59,67)(H,60,65)(H,68,69)(H4,48,49,52)(H4,50,51,53)/t27-,28-,29-,30-,31-,32-,34-/m0/s1

InChIKey=KFGJOYGOLBHNEQ-SLJYAKFTSA-N

Immunomodulating peptide according to the BIOPEP-UWM database of bioactive peptides (ID 3056)


Database reference:

BIOPEP-UWM database of bioactive peptides: ID 3056

PepBank: Peptide GKVLKKRR

PubChem: CID 134826239