BIOPEP-UWM: Report

ID 7796
Name Lipoxygenase inhibitor
sequence
VKEAMAPK
Function:
Inhibition activity against Lox-catalyzed linoleate oxidation (initial rate kinetics) amounted to 16%
 
Number of residues
8
Activity code
lox
Activity :
lipoxygenase inhibitor
Chemical mass 873.0703 Monoisotopic mass 872.4774
EC50 :
0.00 µM


Bibliographic data:
Authors
Rival S. G., Fornaroli S., Boeriu C. G., Wichers H. J.
Title
Caseins and casein hydrolysates. 1. Lipoxygenase inhibitory properties. J. Agric. Food Chem., 49, 287-294, 2001
Year Source
2001 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCCN)C(=O)O

InChI=1S/C38H68N10O11S/c1-21(2)30(41)36(56)46-24(11-6-8-17-39)34(54)45-25(14-15-29(49)50)32(52)42-22(3)31(51)44-26(16-20-60-5)33(53)43-23(4)37(57)48-19-10-13-28(48)35(55)47-27(38(58)59)12-7-9-18-40/h21-28,30H,6-20,39-41H2,1-5H3,(H,42,52)(H,43,53)(H,44,51)(H,45,54)(H,46,56)(H,47,55)(H,49,50)(H,58,59)/t22-,23-,24-,25-,26-,27-,28-,30-/m0/s1

InChIKey=VOUISVGLJNTLLA-ZUSSBPFISA-N



Fermented by Lb. rhamnosus + digestion with pepsin and Corolase PP. Peptide obtained by hydrolysis of bovine beta-casein by use of trypsin .


Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9561), the DFBP database

Predicted antithrombotic peptides according to the BIOPEP-UWM Virtual database; the DFBP database


Database reference:
BIOPEP-UWM database of bioactive peptides: ID 9561

BIOPEP-UWM Virtual database: ID 211

DFBP: DFBPANOX0125; DFBPANTH0153