BIOPEP-UWM: Report

ID 8352
Name ACE inhibitor from cuttlefish (Sepia officinalis)
sequence
RSIKGF

Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
6
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 706.8312 Monoisotopic mass 706.4114
IC50 :
32.74 µM



Bibliographic data:
Authors
Balti R., Bougatef A., Sila A., Guillochon D., Dhulster P., Nedjar-Arroume N.
Title
Nine novel angiotensin I-converting enzyme (ACE) inhibitory peptides from cuttlefish (Sepia officinalis) muscle protein hydrolysates and antihypertensive effect of the potent active peptide in spontaneously hypertensive rats. Food Chem., 170, 519-525
Year Source
2015 Journal



Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CCCCN)C(=O)NCC(=O)N[C@@]([H])(Cc1ccccc1)C(=O)O

InChI=1S/C32H54N10O8/c1-3-19(2)26(42-29(47)24(18-43)41-27(45)21(34)12-9-15-37-32(35)36)30(48)40-22(13-7-8-14-33)28(46)38-17-25(44)39-23(31(49)50)16-20-10-5-4-6-11-20/h4-6,10-11,19,21-24,26,43H,3,7-9,12-18,33-34H2,1-2H3,(H,38,46)(H,39,44)(H,40,48)(H,41,45)(H,42,47)(H,49,50)(H4,35,36,37)/t19-,21-,22-,23-,24-,26-/m0/s1

InChIKey=NAADMAYAQXLGQC-PSEZLDIXSA-N



Database reference:
FeptideDB: ID 8352