BIOPEP-UWM: Report

ID 8388
Name ACE inhibitor from egg yolk protein
sequence
LAPSLPGKPKPD
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
12
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 1219.4260 Monoisotopic mass 1218.6950
EC50 :
1.97 µM


Bibliographic data:
Authors
Eckert E., Zambrowicz A., Pokora M., Setner B., Dąbrowska A., Szołtysik M., Szewczuk Z., Polanowski A., Trziszka T., Chrzanowska J.
Title
Egg-yolk protein by-product as a source of ACE-inhibitory peptides obtained with using unconventional proteinase from Asian pumpkin (Cucurbita ficifolia). Journal of Proteomics 110, 107-116, 2014
Year Source
2014 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCCN)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(=O)O)C(=O)O

InChI=1S/C56H94N14O16/c1-31(2)26-34(59)46(75)61-33(5)52(81)67-22-11-17-41(67)51(80)66-39(30-71)47(76)64-37(27-32(3)4)55(84)68-23-10-16-40(68)48(77)60-29-44(72)62-35(14-6-8-20-57)53(82)69-24-12-18-42(69)49(78)63-36(15-7-9-21-58)54(83)70-25-13-19-43(70)50(79)65-38(56(85)86)28-45(73)74/h31-43,71H,6-30,57-59H2,1-5H3,(H,60,77)(H,61,75)(H,62,72)(H,63,78)(H,64,76)(H,65,79)(H,66,80)(H,73,74)(H,85,86)/t33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-/m0/s1

InChIKey: GPHDNVHMTOABLZ-QMOUKIQXSA-N


Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8547)
Inhibitor of alpha-glucosidase (EC 3.2.1.20) according to the BIOPEP-UWM database of bioactive peptides (ID 8548)
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8550)


Database reference:
BIOPEP-UWM database of bioactive peptides: ID 8547; 8548; 8550