BIOPEP-UWM: Report

ID 8501
Name Dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
sequence
IP
Function:
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
 
Number of residues
2
Activity code
dpp
Activity :
dipeptidyl peptidase IV inhibitor
Chemical mass 228.2873 Monoisotopic mass 228.1469
EC50 :
410.00 µM


Bibliographic data:
Authors
Hatanaka T., Inoue Y., Arima J., Kumagai Y., Usuki H., Kawakami K., Kimura M., Mukaihara T.
Title
Production of dipeptidyl peptidase IV inhibitory peptides from defated rice bran. Food Chem., 134, 797-802, 2012
Year Source
2012 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])([C@]([H])(CC)C)C(=O)N1[C@@]([H])(CCC1)C(=O)O

InChI=1S/C11H20N2O3/c1-3-7(2)9(12)10(14)13-6-4-5-8(13)11(15)16/h7-9H,3-6,12H2,1-2H3,(H,15,16)/t7-,8-,9-/m0/s1

InChIKey=BBIXOODYWPFNDT-CIUDSAMLSA-N


Alternative IC50 value 149,6 micromoles:
Nongonierma A. B., FitzGerald R. J. 2013, Inhibition of dipeptidyl peptidase IV (DPP-IV) by proline containing casein-derived peptides. J. Funct. Foods, 5, 1909-1917

Another reference concerning peptide:
Stöckel-Maschek A., Stiebitz B., Faust J., Born I., Kähne T., Gorrell M. D., Neubert K., 2003, Different inhibition mechanisms of dipeptidyl peptidase IV by tryptophan containing peptides and amides. Adv. Exp. Med. Biol., 524, 69-72



Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database; the BindingDB database; the BIOPEP-UWM database of bioactive peptides (ID 7581); the ChEMBL database; the EROP-Moscow database; the MBPDB database

Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 489); the ChEMBL database; the EROP-Moscow database


Database reference:
AHTPDB: ID 1501, 3018, 3075, 3220, 3352, 3418, 3500, 3565, 3788, 3862, 3952, 4443, 4494, 4673, 5865, 6567

BindingDB: ID 50348850

BioPepDB: ID biopep00554

BIOPEP-UWM database of bioactive peptides: ID 7581

BIOPEP-UWM database of sensory peptides and amino acids: ID 489

BRENDA: Ligand Ile-Pro

ChEBI:ID 74076

ChEMBL: ID CHEMBL1807684

ChemSpider: ID 392673

EPA CompTox: ID DTXSID70332168

EPA DSSTox: ID DTXCID70283262

EROP-Moscow: ID E09205

FeptideDB: ID 7581; 8501

HMDB: ID HMDB0011174

J-GLOBAL: ID 200907051126439176

MBPDB: peptide IP

Metabolights: ID MTBLC74076

Nikkaji: ID J608.440K

PlantPepDB: ID PPepDB_3826

PubChem: CID 444876

SATPdb: ID satpdb19409

SureChEMBL: ID SCHEMBL231857

ZINC: ID ZINC000001591038