BIOPEP-UWM: Report

ID 8504
Name Dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
sequence
WP

Function:
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
 
Number of residues
2
Activity code
dpp
Activity :
dipeptidyl peptidase IV inhibitor
Chemical mass 301.3396 Monoisotopic mass 301.1422
EC50 :
4530.00 µM



Bibliographic data:
Authors
Hatanaka T., Inoue Y., Arima J., Kumagai Y., Usuki H., Kawakami K., Kimura M., Mukaihara T.
Title
Production of dipeptidyl peptidase IV inhibitory peptides from defatted rice bran. Food Chem., 134, 797-802
Year Source
2012 Journal



Additional information:
BIOPEP database of bioactive peptides


SMILES: N[C@H](C(=O)N1[C@H](C(=O)O)CCC1)Cc1c[nH]c2c1cccc2

InChI=1S/C16H19N3O3/c17-12(15(20)19-7-3-6-14(19)16(21)22)8-10-9-18-13-5-2-1-4-11(10)13/h1-2,4-5,9,12,14,18H,3,6-8,17H2,(H,21,22)/t12-,14-/m0/s1

InChIKey: DXYQIGZZWYBXSD-JSGCOSHPSA-N


First reference containing DPPIV inhibitory activity:
Yamada M., Okagaki C., Higashijima T., Tanaka S., Ohnuki T., Sugita T., 1998, A potent dipeptide inhibitor of dipeptidyl peptidase IV. Bioorg. Med. Chem. Lett., 8, 1537-1540


Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: XM02-001) according to AHTPDB database, EROP-Moscow database

Bitter peptide according to BIOPEP database of sensory peptides and amino acids



Database reference:
AHTPDB: ID 2795

BIOPEP database of sensory peptides and amino acids: ID 341

BRENDA: Ligand Trp-Pro

ChEMBL: ID CHEMBL417328

ChemSpider: ID 8015051

EROP-Moscow: ID E10414

PubChem: ID 9839333

ZINC: ID ZINC02572698