BIOPEP-UWM: Report

ID 8521
Name dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
sequence
YP
Function:
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
 
Number of residues
2
Activity code
dpp
Activity :
dipeptidyl peptidase IV inhibitor
Chemical mass 278.3030 Monoisotopic mass 278.1262
IC50 :
3170.00 µM


Bibliographic data:
Authors
Hatanaka T., Inoue Y., Arima J., Kumagai Y., Usuki H., Kawakami K., Kimura M., Mukaihara T.
Title
Production of dipeptidyl peptidase IV inhibitory peptides from defatted rice bran. Food Chem., 134, 797-802, 2012
Year Source
2012 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@H](C(=O)N1[C@H](C(=O)O)CCC1)Cc1ccc(cc1)O

InChI=1S/C14H18N2O4/c15-11(8-9-3-5-10(17)6-4-9)13(18)16-7-1-2-12(16)14(19)20/h3-6,11-12,17H,1-2,7-8,15H2,(H,19,20)/t11-,12-/m0/s1

InChIKey: VNYDHJARLHNEGA-RYUDHWBXSA-N


Another IC50 value: 658.1 micromoles - according to:
Nongonierma A. B., FitzGerald R. J., 2013, Inhibition of dipeptidyl peptidase IV (DPP-IV) by proline containing casein-derived peptides. J. Funct. Foods, 5, 1909-1917

The peptide is a hemoglobin fragment:
Lantz I., Glämsta E.-L., Tälback L., Nyberg F., 1991, Hemorphins derived from hemoglobin have an inhibitory action on angiotensin-converting enzyme activity. FEBS Lett., 287, 39-41

Peptide found also in amaranth protein hydrolysate.
Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111


Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database; the BindingDB database; the BIOPEP-UWM database of bioactive peptides (ID 3666); the BRENDA database; the ChEMBL database; the EROP-Moscow database (ID E09272); the PubChem database
Inhibitor of alpha-glucosidase (EC 3.2.1.20) according to the BIOPEP-UWM database of bioactive peptides (ID 9548)

Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids


Database reference:
AHTPDB: ID 1213; 1344; 1349; 1386; 1673; 1706; 2683; 2981; 2985; 3111; 3405; 3551; 3638; 4055; 4130; 4176; 4951; 5574; 5638; 6474

BindingDB: ID 50348856

BioPepDB: ID biopep01590

BIOPEP-UWM database of bioactive peptides: ID 3666; 9548

BIOPEP-UWM database of sensory peptides and amino acids; ID 71

BRENDA: Ligand Tyr-Pro

ChEBI: ID 141456

ChEMBL: ID CHEMBL1807689

ChemSpider: ID 7971403

EPA DSSTox: ID DTXCID90381673

EROP-Moscow: ID E06297; E09272

J-GLOBAL: ID 200907049822444422

Nikkaji: ID J453.042J

PubChem: CID 9795637

SATPdb: ID satpdb19838

SureChEMBL: ID SCHEMBL5336562

ZINC: ID ZINC04899652