BIOPEP-UWM: Report

ID 8750
Name Alpha-glucosidase inhibitor from egg yolk
sequence
YINQMPQKSREA
Function:
Inhibitor of alpha-glucosidase (EC 3.2.1.20)
 
Number of residues
12
Activity code
glui
Activity :
alpha-glucosidase inhibitor
Chemical mass 1464.6427 Monoisotopic mass 1463.7168
IC50 :
310.31 µM


Bibliographic data:
Authors
Zambrowicz A., Pokora M., Setner B., Dąbrowska A., Szołtysik M., Babij K., Szewczuk Z., Trziszka T., Lubec G., Chrzanowska J.
Title
Multifunctional peptides derived from an egg yolk protein hydrolysate: isolation and characterization. Amino Acids 47, 369-380, 2015
Year Source
2015 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: [H][C@](N)(Cc1ccc(O)cc1)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCSC)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CCC(O)=O)C(=O)N[C@@]([H])(C)C(O)=O

InChI=1S/C62H101N19O20S/c1-5-31(2)49(80-50(89)35(64)28-33-13-15-34(83)16-14-33)59(98)78-42(29-47(67)86)56(95)75-38(17-20-45(65)84)55(94)77-41(23-27-102-4)60(99)81-26-9-12-44(81)58(97)76-39(18-21-46(66)85)54(93)72-36(10-6-7-24-63)53(92)79-43(30-82)57(96)73-37(11-8-25-70-62(68)69)52(91)74-40(19-22-48(87)88)51(90)71-32(3)61(100)101/h13-16,31-32,35-44,49,82-83H,5-12,17-30,63-64H2,1-4H3,(H2,65,84)(H2,66,85)(H2,67,86)(H,71,90)(H,72,93)(H,73,96)(H,74,91)(H,75,95)(H,76,97)(H,77,94)(H,78,98)(H,79,92)(H,80,89)(H,87,88)(H,100,101)(H4,68,69,70)/t31-,32-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,49-/m0/s1

InChIKey: ZKZQTINMABVXFI-CACLQLEZSA-N


Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the BIOPEP-UWM database of bioactive peptide (ID 8744)
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptide (ID 8740)


Database reference:
BIOPEP-UWM database of bioactive peptides: ID 8740; 8744