BIOPEP-UWM: Report

ID 8922
Name dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
sequence
VL
Function:
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
 
Number of residues
2
Activity code
dpp
Activity :
dipeptidyl peptidase IV inhibitor
Chemical mass 230.3031 Monoisotopic mass 230.1625
EC50 :
74.00 µM


Bibliographic data:
Authors
Lan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.
Title
Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73, 2015
Year Source
2015 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@H](C(=O)N[C@H](C(=O)O)CC(C)C)C(C)C

InChI=1S/C11H22N2O3/c1-6(2)5-8(11(15)16)13-10(14)9(12)7(3)4/h6-9H,5,12H2,1-4H3,(H,13,14)(H,15,16)/t8-,9-/m0/s1

InChIKey: XCTHZFGSVQBHBW-IUCAKERBSA-N


Peptide found in whey protein hydrolysate:
Morifuji M., Koga J., Kawanaka K., Higuchi M., 2009, Branched-chain amino acid-containing dipeptides, identified from whey protein hydrolysates, stimulate glucose uptake in L6 myotubes and isolated skeletal muscles. J. Nutr. Sci. Vitaminol., 55, 81-86

Le Maux S., Nongonierma A. B., Murray B., Kelly P. M., FitzGerald R. J., 2015, Identification of short peptide sequences in the nanofiltration permeate of a bioactive whey protein hydrolysate. Food Res. Int., 77, 534-539.


Glucose uptake stimulating activity according to the BIOPEP-UWM database of bioactive peptides (ID 8320)
Inhibitor of citrulline uptake in yeasts according to the ChEMBL database
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database; the PlantPepDB database

Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 110); the ChEMBL database


Database reference:
BioPepDB: ID biopep01406

BIOPEP-UWM database of bioactive peptides: ID 8320

BIOPEP-UWM database of sensory peptides and amino acids: ID 110

BRENDA: ligand Val-Leu

ChEBI: ID 75013

ChEMBL: ID CHEMBL55044

ChemSpider: ID 5361221

ECHA: Substance N-L-valyl-L-leucine

EROP-Moscow: ID E23684

FeptideDB: ID 8320; 8922

FooDB: ID FDB112133

HMDB: ID HMDB0029131

J-GLOBAL: ID 200907052771268315

MBPDB: peptide VL

MeSH: Term Val-Leu

Metabolights: ID MTBLC75013

Nikkaji: ID J149.654I

PlantPepDB: ID PPepDB_210

PubChem: CID 6993117

SureChEMBL: ID SCHEMBL79236

ZINC: ID ZINC000001605723