BIOPEP-UWM: Report

ID 8929
Name dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
sequence
VY
Function:
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
 
Number of residues
2
Activity code
dpp
Activity :
dipeptidyl peptidase IV inhibitor
Chemical mass 280.3188 Monoisotopic mass 280.1418
EC50 :
0.00 µM


Bibliographic data:
Authors
Lan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.
Title
Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73, 2015
Year Source
2015 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O

InChI=1S/C14H20N2O4/c1-8(2)12(15)13(18)16-11(14(19)20)7-9-3-5-10(17)6-4-9/h3-6,8,11-12,17H,7,15H2,1-2H3,(H,16,18)(H,19,20)/t11-,12-/m0/s1

InChIKey: VEYJKJORLPYVLO-RYUDHWBXSA-N


Found in sake and sake by-products:

Saito Y., Wanezaki K., Kawato A., Imayasu S., 1994, Structure and activity of angiotensin I converting enzyme inhibitory peptides from sake and sake lees. Biosci. Biotech. Biochem., 58, 1767-1771

found in wheat milling by-products:

Nogata Y., Nagamine T., Yanaka M., Ohta H., 2009, Angiotensin I converting enzyme inhibitory peptides produced by autolysis reactions from wheat bran. J. Agric. Food Chem., 57, 6618-6622;

found in potato protein hydrolysates:

Cheng Y., Chen J., Xiong Y. L., 2010, Chromatographic separation and tandem MS identification of active peptides in potato protein hydrolysate that inhibit autoxidation of soybean oil-in-water emulsions. J. Agric. Food Chem., 58, 8825-8832;

found in amaranth protein hydrolysate:

Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111

Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database; the BIOPEP database of bioactive peptides (ID 3492); the BRENDA database; the ChEMBL database; the EROP-Moscow database
Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8224)
Inhibitor of Tripeptidyl peptidase 2 (TPP 2) (EC 3.4.14.10) (MEROPS ID: S08.090) according to the BRENDA database; the ChEMBL database
Inhibitor of Dipeptidyl-peptidase III (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BIOPEP-UWM database of bioactive peptides (ID 9509); the BRENDA database


Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids


Database reference:
AHTPDB: ID 1092; 1111; 1202; 1286; 1401; 1406; 1437; 1439; 1449; 1459; 1461; 1498; 1669; 1854; 1917; 1933; 2026; 2733; 2780; 2935; 2989; 3065; 3167; 3394; 3590; 3594; 3771; 3784; 4050; 4125; 4231; 4241; 4252; 4447; 4456; 4490; 4661; 4945; 4946; 5179; 5451; 5570; 5633; 6151; 6265; 6267; 6281; 6411; 6881

BindingDB: ID 50169147

BioPepDB: ID biopep01501

BIOPEP-UWM database of bioactive peptides: ID 3492; 8224; 9509

BIOPEP-UWM database of sensory peptides and amino acids: ID 103

BRENDA: Ligand Val-Tyr

ChEBI: ID 73703

ChEMBL: ID CHEMBL90069

ChemSpider: ID 5373134

EROP-Moscow database: ID E09051

J-GLOBAL: ID 200907095117777910

MBPDB: Peptide VY

Metabolights: ID MTBLC73703

Nikkaji: ID J149.639E

PubChem: ID 7009554

SATPdb: ID satpdb21554

SDBS: ID SDBS-4359

SureChEMBL: ID SCHEMBL4273366

ZINC: ID ZINC000002384776