BIOPEP-UWM: Report

ID 9001
Name VV-hemorphin-7
sequence
VVYPWTQRF

Function:
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001).
 
Number of residues
9
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 1195.3651 Monoisotopic mass 1194.6167
IC50 :
34.30 µM



Bibliographic data:
Authors
Zhao Q., Sannier F., Garreau I., Guillochon, Piot J. M.
Title
Inhibition and inhibition kinetics of angiotensin converting enzyme activity by hemorphins isolated from peptic bovine hydrolysate. Biochem. Biophys. Res. Commun., 204, 216-223, 1994
Year Source
1994 Journal



Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES:
N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CC3=C[N](C4=C3C=CC=C4)[H])C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC5=CC=CC=C5)C(=O)O

InChI=1S/C59H82N14O13/c1-31(2)47(61)54(81)71-48(32(3)4)55(82)69-43(27-35-19-21-37(75)22-20-35)57(84)73-26-12-18-45(73)53(80)68-42(29-36-30-65-39-16-10-9-15-38(36)39)52(79)72-49(33(5)74)56(83)67-41(23-24-46(60)76)51(78)66-40(17-11-25-64-59(62)63)50(77)70-44(58(85)86)28-34-13-7-6-8-14-34/h6-10,13-16,19-22,30-33,40-45,47-49,65,74-75H,11-12,17-18,23-29,61H2,1-5H3,(H2,60,76)(H,66,78)(H,67,83)(H,68,80)(H,69,82)(H,70,77)(H,71,81)(H,72,79)(H,85,86)(H4,62,63,64)/t33-,40+,41+,42+,43+,44+,45+,47+,48+,49+/m1/s1

InChIKey: FFBBHLKDMHCFTH-AKYHLAPZSA-N


Opioid peptide according to the BIOPEP database of bioactive peptides (ID 2570); PepBank database

Bitter peptide according to the BIOPEP database of sensory peptides and amino acids (ID 404)



Database reference:
AHTPDB: ID 1047, 2342, 2739, 2826, 2880, 2923, 3713, 4216, 4474, 4614

BIOPEP-UWM database of bioactive peptides: ID 2570

BIOPEP-UWM database of sensory peptides and amino acids: ID 404

ChemIDplus: ID 075808672

ChemSpider: ID 112435

EROP-Moscow: ID E00289

FeptideDB: ID 2570

J-GLOBAL: ID 200907021779059992

Nikkaji: ID J654.605F

PepBank: peptide VVYPWTQRF

PubChem: CID 126533

SATPdb: ID satpdb17026