BIOPEP-UWM: Report

ID 9003
Name ACE inhibitor from thornback ray muscle (Raja clavata)
sequence
TLKYP
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
5
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 620.7356 Monoisotopic mass 620.3522
IC50 :
170.00 µM


Bibliographic data:
Authors
Lassoued I., Mora L., Barkia, Aristoy M.-C., Nasri M., Toldra F.
Title
Angiotensin I-converting enzyme inhibitory peptides FQPSF and LKYPI identified in Bacillus subtilis A26 hydrolysate of thornback ray muscle. Int. J. Food Sci. Food Technol., 51, 1604-1609.
Year Source
2016 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: CC(C)C[C@@H](C(=N[C@@H](CCCCN)C(=N[C@@H](Cc1ccc(cc1)O)C(=O)N1CCC[C@H]1C(=O)O)O)O)N=C([C@H]([C@@H](C)O)N)O

InChI=1S/C30H48N6O8/c1-17(2)15-22(34-28(41)25(32)18(3)37)27(40)33-21(7-4-5-13-31)26(39)35-23(16-19-9-11-20(38)12-10-19)29(42)36-14-6-8-24(36)30(43)44/h9-12,17-18,21-25,37-38H,4-8,13-16,31-32H2,1-3H3,(H,33,40)(H,34,41)(H,35,39)(H,43,44)/t18-,21+,22+,23+,24+,25+/m1/s1

InChIKey: LRSODGOXWMFTNG-LZFDFFMTSA-N


Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M02-001


Peptide identified in thornback ray muscle (Raja clavata) Bacillus subtilis A26 hydrolysate. IC50 value of synthetic peptide was 170 uM.


Database reference:
EROP-Moscow: ID E25023