BIOPEP-UWM: Report

ID 9004
Name ACE inhibitor from thornback ray muscle (Raja clavata)
sequence
LKYPI
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
5
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 632.7892 Monoisotopic mass 632.3885
EC50 :
27.07 µM


Bibliographic data:
Authors
Lassoued I., Mora L., Barkia A., Aristoy M.-C., Nasri M., Toldra F.
Title
Angiotensin I-converting enzyme inhibitory peptides FQPSF and LKYPI identified in Bacillus subtilis A26 hydrolysate of thornback ray muscle. Int. J. Food Sci. Food Technol., 51, 1604-1609, 2016
Year Source
2016 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@]([H])(C(O)=O)[C@@]([H])(C)CC

InChI=1S/C32H52N6O7/c1-5-20(4)27(32(44)45)37-30(42)26-10-8-16-38(26)31(43)25(18-21-11-13-22(39)14-12-21)36-29(41)24(9-6-7-15-33)35-28(40)23(34)17-19(2)3/h11-14,19-20,23-27,39H,5-10,15-18,33-34H2,1-4H3,(H,35,40)(H,36,41)(H,37,42)(H,44,45)/t20-,23-,24-,25-,26-,27-/m0/s1

InChIKey=FZWDRWMBYFWEJH-BCAOEVRMSA-N

Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M02-001


Peptide identified in thornback ray muscle (Raja clavata) Bacillus subtilis A26 hydrolysate. IC50 value of synthetic peptide was 27.07 uM.


Database reference:
EROP-Moscow: ID E25024