BIOPEP-UWM: Report

ID 9006
Name ACE inhibitor from thornback ray muscle (Raja clavata)
sequence
FQPSF
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
5
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 624.6831 Monoisotopic mass 624.2898
IC50 :
12.56 µM


Bibliographic data:
Authors
Lassoued I., Mora L., Barkia A., Aristoy M.-C., Nasri M., Toldra F.
Title
Angiotensin I-converting enzyme inhibitory peptides FQPSF and LKYPI identified in Bacillus subtilis A26 hydrolysate of thornback ray muscle. Int. J. Food Sci. Food Technol., 51, 1604-1609, 2016
Year Source
2016 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)O

InChI=1S/C31H40N6O8/c32-21(16-19-8-3-1-4-9-19)27(40)34-22(13-14-26(33)39)30(43)37-15-7-12-25(37)29(42)36-24(18-38)28(41)35-23(31(44)45)17-20-10-5-2-6-11-20/h1-6,8-11,21-25,38H,7,12-18,32H2,(H2,33,39)(H,34,40)(H,35,41)(H,36,42)(H,44,45)/t21-,22-,23-,24-,25-/m0/s1

InChIKey: SFLLIXBWZURJIL-KEOOTSPTSA-N


Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M02-001



Peptide identified in thornback ray muscle (Raja clavata) Bacillus subtilis A26 hydrolysate. IC50 value of synthetic peptide was 12.56 uM.


Database reference:
EROP-Moscow: ID E25025