BIOPEP-UWM: Report

ID 9072
Name ACE inhibitor
sequence
DY
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
2
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 296.2753 Monoisotopic mass 296.1004
IC50 :
100.00 µM


Bibliographic data:
Authors
Wu J., Aluko R. E., Nakai S.
Title
Structural requirements of angiotensin I-converting enzyme inhibitory activity: quantitative structure-activity relationship study of di- and tripeptides. J. Agric. Food Chem., 54, 732-738, 2006
Year Source
2006 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)O

InChI=1S/C13H16N2O6/c14-9(6-11(17)18)12(19)15-10(13(20)21)5-7-1-3-8(16)4-2-7/h1-4,9-10,16H,5-6,14H2,(H,15,19)(H,17,18)(H,20,21)/t9-,10-/m0/s1

InChIKey: NALWOULWGHTVDA-UWVGGRQHSA-N


Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M02-001


Peptide found in bovine collagen hydrolysate:

Herregods G., Van Camp J., Morel N., Ghesquière B., Gevaert K., Vercruysse L., Dierckx S., Quanten E., Smagghe G., 2011, Angiotensin I-converting enzyme inhibitory activity of gelatin hydrolysates and identification of bioactive peptides. J. Agric. Food Chem., 59, 552-558


Ion flow regulating peptide according to the BIOPEP-UWM database of bioactive peptides (ID 2749); the EROP-Moscow database


Bitter peptide according to the BIOPEP database of sensory peptides and amino acids; the ChEMBL database; the PubChem database


Database reference:
ACToR: ID 22840-03-5

AHTPDB: ID 1350, 4215, 4954

BindingDB: ID 50049712

BioPepDB: ID biopep00157

BIOPEP-UWM database of bioactive peptides: ID 2749

BIOPEP-UWM database of sensory peptides and amino acids: ID 480

Brenda: Ligand Asp-Tyr

ChEBI: ID 73455

ChEMBL: ID CHEMBL171132

ChemSpider: ID 134366

EPA CompTox: ID DTXSID20177389

EPA DSSTox: ID DTXCID3099880

EROP-Moscow: ID E01600

J-GLOBAL: ID 200907055017390758

Metabolights: ID MTBLC73455

Nikkaji: ID J861.377J

PubChem: CID 152455

SATPdb: ID satpdb22485

SureChEMBL: ID SCHEMBL7935661

ZINC: ID ZINC000002391137