BIOPEP-UWM: Report

ID 9107
Name ACE inhibitor
sequence
WL
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
2
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 317.3819 Monoisotopic mass 317.1734
IC50 :
41.40 µM


Bibliographic data:
Authors
Khedr S., Martin M., Deussen A.
Title
Inhibitory efficacy and biological variability of tryptophan containing dipeptides on human plasma angiotensin converting enzyme activity. J. Hypertens., 4, Article No 1000198, 2015
Year Source
2015 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: CC(C)C[C@H](NC(=O)[C@@H](N)CC1=CNC2=CC=CC=C12)C(O)=O

InChI=1S/C17H23N3O3/c1-10(2)7-15(17(22)23)20-16(21)13(18)8-11-9-19-14-6-4-3-5-12(11)14/h3-6,9-10,13,15,19H,7-8,18H2,1-2H3,(H,20,21)(H,22,23)/t13-,15-/m0/s1

InChIKey: LYMVXFSTACVOLP-ZFWWWQNUSA-N


Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M02-001

Activity measured using rabbit lung ACE. Activities measured against human plasma ACE and human recombinant ACE, are 81.6 and 85.3 micromoles respectively.
Khedr S., Martin M., Deussen A., 2015, Inhibitory efficacy and biological variability of tryptophan containing dipeptides on human plasma angiotensin converting enzyme activity. J. Hypertens., 4, Article No 1000198

Inhibitor of Peroxisome proliferator-activated receptor gamma according to BindingDB database; ChEMBL database
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8677)

Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids; the BitterDB database


Database reference:
AHTPDB: ID 1463; 1900; 2968; 4724; 5181; 6216; 6220; 6862

BindingDB: ID 50266681

BIOPEP-UWM database of bioactive peptides: ID 8677

BIOPEP-UWM database of sensory peptides and amino acids: ID 338

BRENDA: Ligand Trp-Leu

BitterDB: ID 830

ChEBI: ID 74871

ChEMBL: ID CHEMBL477627

ChemSpider: ID 5365198

EROP-Moscow: ID E06385

J-GLOBAL: ID 200907089186452560

Nikkaji: ID J236.159K

PubChem: ID 6997509

SATPdb: ID satpdb20928

Therapeutic Target Database (TTD): ID DNC009657

ZINC: ID ZINC01865984