BIOPEP-UWM: Report

ID 9168
Name HMG-CoA reductase inhibitor
sequence
GGYVAE
Function:
Inhibitor of HMG-CoA reductase (EC 1.1.1.34)
 
Number of residues
6
Activity code
HMGi
Activity :
HMG-CoA reductase inhibitor
Chemical mass 594.6126 Monoisotopic mass 594.2640
IC50 :
7.40 µM


Bibliographic data:
Authors
Pak V. V., Koo M., Kim M. J., Yang H. J., Yun L., Kwon D. Y.
Title
Modeling an active conformation for linear peptides and design of a competitive inhibitor for HMG-CoA reductase. J. Mol. Recognit., 21, 224–232, 2008
Year Source
2008 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: NCC(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)O

InChI=1S/C26H38N6O10/c1-13(2)22(25(40)29-14(3)23(38)31-17(26(41)42)8-9-21(36)37)32-24(39)18(10-15-4-6-16(33)7-5-15)30-20(35)12-28-19(34)11-27/h4-7,13-14,17-18,22,33H,8-12,27H2,1-3H3,(H,28,34)(H,29,40)(H,30,35)(H,31,38)(H,32,39)(H,36,37)(H,41,42)/t14-,17-,18-,22-/m0/s1

InChIKey: ULHVASQUOFFZHE-GQAKTHPZSA-N


HMG-CoA reductase (EC 1.1.1.34) is involved in cholesterol biosynthesis.


Database reference: