BIOPEP-UWM: Report

ID 9180
Name Cytotoxic peptide
sequence
KENPVLSLVNGMF
Function:
Cytotoxic peptide
 
Number of residues
13
Activity code
tox
Activity :
toxic
Chemical mass 1447.6948 Monoisotopic mass 1446.7516
EC50 :
0.00 µM


Bibliographic data:
Authors
Quah Y., Mohd Ismail N. I., Ooi J. L. S., Affendi Y. A., Manan F. A., Wong F-C, Chai T-T
Title
Identification of novel cytotoxic peptide KENPVLSLVNGMF from marine sponge Xestospongia testudinaria, with characterization of stability in human serum. Int. J. Pept. Res. Ther. 24, 189-199, 2018
Year Source
2018 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)NCC(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)O

InChI=1S/C65H106N16O19S/c1-33(2)26-41(74-63(97)53(36(7)8)80-61(95)47-19-15-24-81(47)64(98)44(30-49(69)84)76-56(90)39(20-21-51(86)87)72-54(88)38(67)18-13-14-23-66)58(92)78-46(32-82)60(94)73-42(27-34(3)4)59(93)79-52(35(5)6)62(96)75-43(29-48(68)83)55(89)70-31-50(85)71-40(22-25-101-9)57(91)77-45(65(99)100)28-37-16-11-10-12-17-37/h10-12,16-17,33-36,38-47,52-53,82H,13-15,18-32,66-67H2,1-9H3,(H2,68,83)(H2,69,84)(H,70,89)(H,71,85)(H,72,88)(H,73,94)(H,74,97)(H,75,96)(H,76,90)(H,77,91)(H,78,92)(H,79,93)(H,80,95)(H,86,87)(H,99,100)/t38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,52-,53-/m0/s1

InChIKey: PGPNFXSGRSBJRD-SEAZOCHXSA-N


Cytotoxic against HeLa cells (EC50 0.67 mM) but non-cytotoxic against non-cancerous Hek293 cells.

KENPVLSLVNGMF was more cytotoxic to Hela cells compared with anticancer drug 5-fluorouracil (EC50 2.56 mM).


Database reference: