BIOPEP-UWM: Report

ID 9312
Name Precursor of antifungal peptide
sequence
KKLFKKILKKLG
Function:
Precursor of antifungal peptide
 
Number of residues
12
Activity code
af
Activity :
antifungal
Chemical mass 1443.8995 Monoisotopic mass 1443.0035
EC50 :
0.00 µM


Bibliographic data:
Authors
Badosa E., Ferré R., Francés J., Bardají E., Feliu L., Planas M., Montesinos E.
Title
Sporicidal activity of synthetic antifungal undecapeptides and control of Penicillium rot of apples. Applied and Environmental Microbiology, 75, 5563–5569, 2009
Year Source
2009 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: [H][C@](N)(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(O)=O

InChI=1S/C71H130N18O13/c1-9-47(8)60(71(102)88-57(41-46(6)7)68(99)83-51(29-15-21-35-74)63(94)81-53(31-17-23-37-76)66(97)85-55(39-44(2)3)62(93)79-43-59(90)91)89-67(98)54(32-18-24-38-77)82-64(95)52(30-16-22-36-75)84-70(101)58(42-48-25-11-10-12-26-48)87-69(100)56(40-45(4)5)86-65(96)50(28-14-20-34-73)80-61(92)49(78)27-13-19-33-72/h10-12,25-26,44-47,49-58,60H,9,13-24,27-43,72-78H2,1-8H3,(H,79,93)(H,80,92)(H,81,94)(H,82,95)(H,83,99)(H,84,101)(H,85,97)(H,86,96)(H,87,100)(H,88,102)(H,89,98)(H,90,91)/t47-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,60-/m0/s1

InChIKey: HWTNYRPKFKHVNL-BPRBMRDNSA-N


The active form is C-terminal amide group instead of C-terminal glycine residue.

Peptide is the precursor of antifungal one (ID 9291 in BIOPEP-UWM database of bioactive peptides).

Reviews concerning C-terminal amidation of peptides:

Bradbury A. F., Smyth D. G., 1991, Peptide amidation. Trends Biochem. Sci., 16, 112-115

Merkler D. J., 1994, C-terminal amidated peptides: production by the in vitro enzymatic amidation of glycine-extended peptides and the importance of the amide to bioactivity. Enzyme Microb. Technol., 16, 450-456


Database reference: