BIOPEP-UWM: Report

ID 9322
Name Precursor of hemolytic peptide
sequence
WKLFKKILKYLG
Function:
Precursor of hemolytic peptide
 
Number of residues
12
Activity code
he
Activity :
haemolytic
Chemical mass 1536.9383 Monoisotopic mass 1535.9563
EC50 :
0.00 µM


Bibliographic data:
Authors
Badosa E., Ferré R., Francés J., Bardají E., Feliu L., Planas M., Montesinos E.
Title
Sporicidal activity of synthetic antifungal undecapeptides and control of Penicillium rot of apples. Applied and Environmental Microbiology, 75, 5563–5569, 2009
Year Source
2009 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: [H][C@](N)(Cc1c[nH]c2ccccc12)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(O)=O

InChI=1S/C79H125N17O14/c1-9-50(8)68(79(110)95-64(41-49(6)7)75(106)89-60(29-17-21-37-82)73(104)93-66(43-52-31-33-54(97)34-32-52)78(109)91-62(39-47(2)3)70(101)86-46-67(98)99)96-74(105)61(30-18-22-38-83)88-71(102)59(28-16-20-36-81)90-77(108)65(42-51-23-11-10-12-24-51)94-76(107)63(40-48(4)5)92-72(103)58(27-15-19-35-80)87-69(100)56(84)44-53-45-85-57-26-14-13-25-55(53)57/h10-14,23-26,31-34,45,47-50,56,58-66,68,85,97H,9,15-22,27-30,35-44,46,80-84H2,1-8H3,(H,86,101)(H,87,100)(H,88,102)(H,89,106)(H,90,108)(H,91,109)(H,92,103)(H,93,104)(H,94,107)(H,95,110)(H,96,105)(H,98,99)/t50-,56-,58-,59-,60-,61-,62-,63-,64-,65-,66-,68-/m0/s1

InChIKey: VCGBMGSIXAIMRW-MSFHQQHDSA-N



The active form is C-terminal amide group instead of C-terminal glycine residue.

Peptide is the precursor of hemolytic one (ID 9299 in BIOPEP-UWM database of bioactive peptides).

Reviews concerning C-terminal amidation of peptides:

Bradbury A. F., Smyth D. G., 1991, Peptide amidation. Trends Biochem. Sci., 16, 112-115

Merkler D. J., 1994, C-terminal amidated peptides: production by the in vitro enzymatic amidation of glycine-extended peptides and the importance of the amide to bioactivity. Enzyme Microb. Technol., 16, 450-456


Precursor of antifungal peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9319)


Database reference:
BIOPEP-UWM database of bioactive peptides: ID 9319