BIOPEP-UWM: Report

ID 9470
Name Renin inhibitor
sequence
LY
Function:
Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID A01.007)
 
Number of residues
2
Activity code
ren
Activity :
renin inhibitor
Chemical mass 294.3453 Monoisotopic mass 294.1574
IC50 :
1870.00 µM


Bibliographic data:
Authors
He R., Malomo S. A., Alashi A., Girgih A. T., Ju X., Aluko R. E.
Title
Purification and hypotensive activity of rapeseed protein derived renin and angiotensin converting enzyme inhibitory peptides. J. Funct. Foods, 5, 781-789, 2013
Year Source
2013 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(O)=O

InChI=1S/C15H22N2O4/c1-9(2)7-12(16)14(19)17-13(15(20)21)8-10-3-5-11(18)6-4-10/h3-6,9,12-13,18H,7-8,16H2,1-2H3,(H,17,19)(H,20,21)/t12-,13-/m0/s1

InChIKey=LHSGPCFBGJHPCY-STQMWFEESA-N


Peptide was obtained from the following resources:

soybean protein hydrolysate
Beermann C., Euler M., Herzberg J., Stahl B., 2009, Anti-oxidative capacity of enzymatically released peptides from soybean protein isolate. Eur. Food Res. Technol., 229, 637–644

amaranth proteins:
Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111

bovine collagen hydrolysate:
Herregods G., Van Camp J., Morel N., Ghesquière B., Gevaert K., Vercruysse L., Dierckx S., Quanten E., Smagghe G., 2011, Angiotensin I-converting enzyme inhibitory activity of gelatin hydrolysates and identification of bioactive peptides. J. Agric. Food Chem., 59, 552-558

Peptide reveals antihypertensive activity in vio in spontaneously hypertensive rats:
He R., Yang Y.-J., Wang Z., Xing C., Yuan J., Wang L.-F., Udenigwe C., Ju X.-R., 2019, Rapeseed protein-derived peptides, LY, RALP, and GHS, modulates key enzymes and intermediate products of renin–angiotensin system pathway in spontaneously hypertensive rat. Sci. Food, 3, 1


Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 7872)
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database; the BindingDB database; the BIOPEP-UWM database of bioactive peptids (ID 3381); the BRENDA database; the ChEMBL database; the EROP-Moscow database; the PubChem database

Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 482)


Database reference:
ACToR: ID 968-21-8

AHTPDB: ID 1096, 1173, 1354, 1358, 1361, 1408, 1976, 2958, 3053, 3055, 3178, 3387, 3520, 3856, 3993, 4099, 4717, 5163, 5546, 5613, 5773, 6174, 6365

BindingDB: ID 50348865

BioPepDB: ID biopep00936

BIOPEP-UWM database of bioactive peptides: ID 3381; 7872

BIOPEP-UWM database of sensory peptides and amino acids: ID 482

BRENDA: Ligand Leu-Tyr

ChEBI: ID 73591

ChEMBL: ID CHEMBL56099

ChemIDplus: ID 968-21-8

ChemSpider: ID 63589

CTD: ID 968-21-8

eChemPortal: ID 968-21-8

EROP-Moscow: ID E01336

J-GLOBAL: ID 200907084889987250

Metabolights: ID MTBLC73591

Nikkaji: ID J80.048A

PubChem: CID 70410

SATPdb: ID satpdb19431

SureChEMBL: ID SCHEMBL2474675

ZINC: ID ZINC000001708202