BIOPEP-UWM: Report

ID 9508
Name DPP-III inhibitor
sequence
YG
Function:
Inhibitor of Dipeptidyl peptidase-III (DPP-III) (EC 3.4.14.4) (MEROPS ID: M49.001)
 
Number of residues
2
Activity code
dpp3
Activity :
dipeptidyl peptidase III inhibitor
Chemical mass 238.2393 Monoisotopic mass 238.0950
EC50 :
0.00 µM


Bibliographic data:
Authors
Dhanda S.; Singh H.; Singh J.
Title
Hydrolysis of various bioactive peptides by goat brain dipeptidylpeptidase-III. Cell Biochem. Funct. 23, 3, 339–345, 2008
Year Source
2008 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(Cc1ccc(O)cc1)C(=O)NCC(=O)O

InChI=1S/C11H14N2O4/c12-9(11(17)13-6-10(15)16)5-7-1-3-8(14)4-2-7/h1-4,9,14H,5-6,12H2,(H,13,17)(H,15,16)/t9-/m0/s1

InChIKey=HPYDSVWYXXKHRD-VIFPVBQESA-N

Information concerning Dipeptidyl peptidase-III (DPP-III) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M49.001)


Peptide found in cod protein hydrolysates:

Geirsdóttir M., 2009, Isolation, purification and investigation of peptides from fish proteins with blood pressure decreasing properties. Report from the project funded by the AVS research fund under the Ministry of Fisheries in Iceland (project no. R-047-07). Matís Report 36-09, Matís, Reykjavik, Iceland, http://www.avs.is/media/avs/36-09_skyrsla_einangrun_peptida.pdf

Found in amaranth (Amarantus hypochondriacus) proteins:

Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111


Inhibitor of Angiotensin-converting enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database, the BindingDB database; the BIOPEP-UWM database of bioactive peptides (ID 3553), the ChEMBL database
Immunomodulating peptide according to the BIOPEP-UWM database of bioactive peptides (ID 2882)
Inhibitor of nitrogen uptake in yeasts according to the ChEMBL database
Inhibitor of Dipeptidyl peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8936)
Inhibitor of Tubulin-tyrosine ligase (EC 6.3.2.25) according to the BRENDA database

Bitter peptide according to BIOPEP database of sensory peptides and amino acids


Database reference:
AHTPDB: ID 1206; 1327; 1351; 1387; 1480; 2998; 3210; 3303; 3548; 3598; 3803; 4053; 4423; 4509; 4656; 5428; 5635; 6467

BindingDB: ID 50188519

BioPepDB: ID biopep01556

BIOPEP-UWM database of bioactive peptides: ID 2882; 3553; 8936

BIOPEP-UWM database of sensory peptides and amino acids: ID 31

BRENDA: Ligand Tyr-Gly

ChEBI: ID 74990

ChEMBL: ID CHEMBL89956

ChemSpider: ID 5384746

EROP-Moscow: ID E09271

HMDB: ID HMDB29105

J-GLOBAL: ID 200907017245435665

Metabolights: ID MTBLC74990

Nikkaji: ID J258.522G

PubChem: ID 7021853

SATPdb: ID satpdb13810

SureChEMBL: ID SCHEMBL4407092

ZINC: ID ZINC000002575475