BIOPEP-UWM: Report

ID 9519
Name DPP-III inhibitor
sequence
HFRW
Function:
Inhibitor of Dipeptidyl peptidase-III (DPP-III) (EC 3.4.14.4) (MEROPS ID: M49.001)
 
Number of residues
4
Activity code
dpp3
Activity :
dipeptidyl peptidase III inhibitor
Chemical mass 644.7224 Monoisotopic mass 644.3175
IC50 :
0.00 µM


Bibliographic data:
Authors
Abramic, M.; Schleuder, D.; Dolovcak, L.; Schroder, W.; Strupat, K.; Sagi, D.; Peter-Katalinic, J.; Vitale, L.
Title
Human and rat dipeptidyl peptidase III, biochemical and mass spectrometric arguments for similarities and differences. Biol. Chem., 381, 12, 1233–1243, 2000
Year Source
2000 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@H](CC1=C[N]([H])C=N1)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC3=C[N]([H])C4=CC=CC=C34)C(=O)O

InChI=1S/C32H40N10O5/c33-23(15-21-17-36-18-39-21)28(43)41-26(13-19-7-2-1-3-8-19)30(45)40-25(11-6-12-37-32(34)35)29(44)42-27(31(46)47)14-20-16-38-24-10-5-4-9-22(20)24/h1-5,7-10,16-18,23,25-27,38H,6,11-15,33H2,(H,36,39)(H,40,45)(H,41,43)(H,42,44)(H,46,47)(H4,34,35,37)/t23-,25-,26-,27-/m0/s1

InChIKey=CAYNQHPLZNPBIO-MNUOIFNESA-N

Information concerning Dipeptidyl peptidase-III (DPP-III) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M49.001)


Ligand of melanocortin receptor 4 according to the BindingDB database; the ChEMBL database


Database reference:
BindingDB: ID 50211182

BRENDA: Ligand His-Phe-Arg-Trp

ChEMBL: ID CHEMBL397413

ChemSpider: ID 8434118

DSigDB: ID d4ttd_5357

J-GLOBAL: ID 200907017649625336

Nikkaji: ID J390.578K

PepBank: Peptide HFRW

PubChem: CID 10258635

TTD: ID DNC007519

ZINC: ID ZINC000028707608