BIOPEP-UWM: Report

ID 9536
Name Precursor of human amylin
sequence
KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTYG
Function:
Precurso of inhibitor of insulin-stimulated glucose processing
 
Number of residues
38
Activity code
inh
Activity :
inhibitor
Chemical mass 3963.3201 Monoisotopic mass 3960.8786
EC50 :
0.00 µM


Bibliographic data:
Authors
Cooper G.J.S., Willis A. C., Clark A., Turner R. C., Sim R. B., Reid K. B. M.
Title
Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients. Proc. Natl Acad. Sci. USA, 84, 8628-8632, 1987
Year Source
1987 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H]([C@H](O)C)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC2=C[N]([H])C=N2)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H]([C@H](CC)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@H](O)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H]([C@H](O)C)C(=O)N[C@@H](CC4=CC=C(C=C4)O)C(=O)NCC(=O)O

InChI=1S/C167H265N51O57S2/c1-22-76(12)126(161(270)201-95(47-72(4)5)142(251)205-109(65-221)155(264)208-111(67-223)156(265)218-131(85(21)228)165(274)204-106(58-120(176)236)149(258)211-124(74(8)9)159(268)182-61-122(238)189-107(63-219)152(261)199-104(56-118(174)234)150(259)217-130(84(20)227)164(273)202-98(138(247)183-62-123(239)240)51-88-38-40-90(229)41-39-88)213-133(242)77(13)185-121(237)60-181-137(246)97(49-86-32-25-23-26-33-86)195-146(255)102(54-116(172)232)197-147(256)103(55-117(173)233)198-153(262)108(64-220)207-154(263)110(66-222)206-144(253)100(52-89-59-179-70-184-89)203-160(269)125(75(10)11)212-148(257)96(48-73(6)7)194-143(252)99(50-87-34-27-24-28-35-87)196-145(254)101(53-115(171)231)192-132(241)78(14)186-141(250)94(46-71(2)3)193-139(248)92(37-31-45-180-167(177)178)190-140(249)93(42-43-114(170)230)191-163(272)128(82(18)225)214-134(243)79(15)187-157(266)112(68-276)210-166(275)129(83(19)226)215-135(244)80(16)188-162(271)127(81(17)224)216-151(260)105(57-119(175)235)200-158(267)113(69-277)209-136(245)91(169)36-29-30-44-168/h23-28,32-35,38-41,59,70-85,91-113,124-131,219-229,276-277H,22,29-31,36-37,42-58,60-69,168-169H2,1-21H3,(H2,170,230)(H2,171,231)(H2,172,232)(H2,173,233)(H2,174,234)(H2,175,235)(H2,176,236)(H,179,184)(H,181,246)(H,182,268)(H,183,247)(H,185,237)(H,186,250)(H,187,266)(H,188,271)(H,189,238)(H,190,249)(H,191,272)(H,192,241)(H,193,248)(H,194,252)(H,195,255)(H,196,254)(H,197,256)(H,198,262)(H,199,261)(H,200,267)(H,201,270)(H,202,273)(H,203,269)(H,204,274)(H,205,251)(H,206,253)(H,207,263)(H,208,264)(H,209,245)(H,210,275)(H,211,258)(H,212,257)(H,213,242)(H,214,243)(H,215,244)(H,216,260)(H,217,259)(H,218,265)(H,239,240)(H4,177,178,180)/t76-,77-,78-,79-,80-,81+,82+,83+,84+,85+,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,124-,125-,126-,127-,128-,129-,130-,131-/m0/s1

InChIKey= ZJSAIBTZZCVEHD-GQTAJQPCSA-N


Peptide is the precursor of human amylin (BIOPEP-UWM database of bioactive peptides: ID 3074).

The active form contains C-terminal amide group instead of C-terminal glycine residue.

Reviews concerning C-terminal amidation of peptides:

Bradbury A. F., Smyth D. G., 1991, Peptide amidation. Trends Biochem. Sci., 16, 112-115

Merkler D. J., 1994, C-terminal amidated peptides: production by the in vitro enzymatic amidation of glycine-extended peptides and the importance of the amide to bioactivity. Enzyme Microb. Technol., 16, 450-456


Database reference: