BIOPEP-UWM: Report

ID 9544
Name ACE inhibitor
sequence
GIPLPLI

Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
7
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 721.9250 Monoisotopic mass 721.4723
IC50 :
74.27 µM



Bibliographic data:
Authors
Ashok A., Brijesha N., Aparna H.S.
Title
Discovery, synthesis, and in vitro evaluation of a novel bioactive peptide for ACE and DPP-IV inhibitory activity. Eur. J. Med. Chem., 180, 99-110, 2019
Year Source
2019 Journal



Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: NCC(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)O

InChI=1S/C15H27N3O4S/c1-9(2)12(16)13(19)17-10(6-8-23-3)14(20)18-7-4-5-11(18)15(21)22/h9-12H,4-8,16H2,1-3H3,(H,17,19)(H,21,22)/t10-,11-,12-/m0/s1

InChIKey: WSUWDIVCPOJFCX-SRVKXCTJSA-N


Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M02-001

Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 9545)







Database reference:
BIOPEP-UWM database of bioactive peptides: ID 9545