BIOPEP-UWM: Report

ID 9581
Name HMG-CoA reductase inhibitor
sequence
FFGYVAE
Function:
Inhibitor of HMG-CoA reductase (EC 1.1.1.34)
 
Number of residues
7
Activity code
HMGi
Activity :
HMG-CoA reductase inhibitor
Chemical mass 831.9084 Monoisotopic mass 831.3790
IC50 :
0.32 µM


Bibliographic data:
Authors
Pak V. V., Koo M., Kwon D. Y., Yun L.
Title
Design of a highly potent inhibitory peptide acting as a competitive inhibitor of HMG-CoA reductase. Amino Acids, 43, 2015-2025, 2012
Year Source
2012 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)O

InChI=1S/C42H53N7O11/c1-24(2)36(41(58)45-25(3)37(54)47-31(42(59)60)18-19-35(52)53)49-40(57)33(22-28-14-16-29(50)17-15-28)46-34(51)23-44-39(56)32(21-27-12-8-5-9-13-27)48-38(55)30(43)20-26-10-6-4-7-11-26/h4-17,24-25,30-33,36,50H,18-23,43H2,1-3H3,(H,44,56)(H,45,58)(H,46,51)(H,47,54)(H,48,55)(H,49,57)(H,52,53)(H,59,60)/t25-,30-,31-,32-,33-,36-/m0/s1

InChIKey: SBMQPFWBQWKYAP-WITQEOTBSA-N


HMG-CoA reductase (EC 1.1.1.34) is involved in cholesterol biosynthesis.


Database reference: