BIOPEP-UWM: Report

ID 9582
Name HMG-CoA reductase inhibitor
sequence
PFGYVAE
Function:
Inhibitor of HMG-CoA reductase (EC 1.1.1.34)
 
Number of residues
7
Activity code
HMGi
Activity :
HMG-CoA reductase inhibitor
Chemical mass 781.8498 Monoisotopic mass 781.3634
IC50 :
0.43 µM


Bibliographic data:
Authors
Pak V. V., Koo M., Kwon D. Y., Yun L.
Title
Design of a highly potent inhibitory peptide acting as a competitive inhibitor of HMG-CoA reductase. Amino Acids, 43, 2015-2025, 2012
Year Source
2012 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)O

InChI=1S/C38H51N7O11/c1-21(2)32(37(54)41-22(3)33(50)43-27(38(55)56)15-16-31(48)49)45-36(53)29(19-24-11-13-25(46)14-12-24)42-30(47)20-40-34(51)28(18-23-8-5-4-6-9-23)44-35(52)26-10-7-17-39-26/h4-6,8-9,11-14,21-22,26-29,32,39,46H,7,10,15-20H2,1-3H3,(H,40,51)(H,41,54)(H,42,47)(H,43,50)(H,44,52)(H,45,53)(H,48,49)(H,55,56)/t22-,26-,27-,28-,29-,32-/m0/s1

InChIKey: QIMDZPSGYKROST-MWGIHYIESA-N


HMG-CoA reductase (EC 1.1.1.34) is involved in cholesterol biosynthesis.


Database reference: