BIOPEP-UWM: Report

ID 9583
Name HMG-CoA reductase inhibitor
sequence
IFGYVAE
Function:
Inhibitor of HMG-CoA reductase (EC 1.1.1.34)
 
Number of residues
7
Activity code
HMGi
Activity :
HMG-CoA reductase inhibitor
Chemical mass 797.8921 Monoisotopic mass 797.3946
IC50 :
0.35 µM


Bibliographic data:
Authors
Pak V. V., Koo M., Kwon D. Y., Yun L.
Title
Design of a highly potent inhibitory peptide acting as a competitive inhibitor of HMG-CoA reductase. Amino Acids, 43, 2015-2025, 2012
Year Source
2012 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)O

InChI=1S/C39H55N7O11/c1-6-22(4)32(40)37(54)45-28(18-24-10-8-7-9-11-24)35(52)41-20-30(48)43-29(19-25-12-14-26(47)15-13-25)36(53)46-33(21(2)3)38(55)42-23(5)34(51)44-27(39(56)57)16-17-31(49)50/h7-15,21-23,27-29,32-33,47H,6,16-20,40H2,1-5H3,(H,41,52)(H,42,55)(H,43,48)(H,44,51)(H,45,54)(H,46,53)(H,49,50)(H,56,57)/t22-,23-,27-,28-,29-,32-,33-/m0/s1

InChIKey: QFLFHASDLFBMSL-BFXDGXOGSA-N


HMG-CoA reductase (EC 1.1.1.34) is involved in cholesterol biosynthesis.


Database reference: