BIOPEP-UWM: Report

ID 9584
Name HMG-CoA reductase inhibitor
sequence
LFGYVAE
Function:
Inhibitor of HMG-CoA reductase (EC 1.1.1.34)
 
Number of residues
7
Activity code
HMGi
Activity :
HMG-CoA reductase inhibitor
Chemical mass 797.8921 Monoisotopic mass 797.3946
IC50 :
0.37 µM


Bibliographic data:
Authors
Pak V. V., Koo M., Kwon D. Y., Yun L.
Title
Design of a highly potent inhibitory peptide acting as a competitive inhibitor of HMG-CoA reductase. Amino Acids, 43, 2015-2025, 2012
Year Source
2012 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)O

InChI=1S/C39H55N7O11/c1-21(2)17-27(40)35(52)45-29(18-24-9-7-6-8-10-24)36(53)41-20-31(48)43-30(19-25-11-13-26(47)14-12-25)37(54)46-33(22(3)4)38(55)42-23(5)34(51)44-28(39(56)57)15-16-32(49)50/h6-14,21-23,27-30,33,47H,15-20,40H2,1-5H3,(H,41,53)(H,42,55)(H,43,48)(H,44,51)(H,45,52)(H,46,54)(H,49,50)(H,56,57)/t23-,27-,28-,29-,30-,33-/m0/s1

InChIKey: BWHFAPHWIDPHDW-PLWDZJMGSA-N


HMG-CoA reductase (EC 1.1.1.34) is involved in cholesterol biosynthesis.


Database reference: