BIOPEP-UWM: Report

ID 9585
Name HMG-CoA reductase inhibitor
sequence
VFGYVAE
Function:
Inhibitor of HMG-CoA reductase (EC 1.1.1.34)
 
Number of residues
7
Activity code
HMGi
Activity :
HMG-CoA reductase inhibitor
Chemical mass 783.8656 Monoisotopic mass 783.3790
IC50 :
0.45 µM


Bibliographic data:
Authors
Pak V. V., Koo M., Kwon D. Y., Yun L.
Title
Design of a highly potent inhibitory peptide acting as a competitive inhibitor of HMG-CoA reductase. Amino Acids, 43, 2015-2025, 2012
Year Source
2012 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)O

InChI=1S/C38H53N7O11/c1-20(2)31(39)36(53)44-27(17-23-9-7-6-8-10-23)34(51)40-19-29(47)42-28(18-24-11-13-25(46)14-12-24)35(52)45-32(21(3)4)37(54)41-22(5)33(50)43-26(38(55)56)15-16-30(48)49/h6-14,20-22,26-28,31-32,46H,15-19,39H2,1-5H3,(H,40,51)(H,41,54)(H,42,47)(H,43,50)(H,44,53)(H,45,52)(H,48,49)(H,55,56)/t22-,26-,27-,28-,31-,32-/m0/s1

InChIKey: JOIWNGHDWKMNLY-LJXGPVSSSA-N


HMG-CoA reductase (EC 1.1.1.34) is involved in cholesterol biosynthesis.


Database reference: