BIOPEP-UWM: Report

ID 9586
Name HMG-CoA reductase inhibitor
sequence
AFGYVAE
Function:
Inhibitor of HMG-CoA reductase (EC 1.1.1.34)
 
Number of residues
7
Activity code
HMGi
Activity :
HMG-CoA reductase inhibitor
Chemical mass 755.8126 Monoisotopic mass 755.3478
IC50 :
0.49 µM


Bibliographic data:
Authors
Pak V. V., Koo M., Kwon D. Y., Yun L.
Title
Design of a highly potent inhibitory peptide acting as a competitive inhibitor of HMG-CoA reductase. Amino Acids, 43, 2015-2025, 2012
Year Source
2012 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: N[C@@]([H])(C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)O

InChI=1S/C36H49N7O11/c1-19(2)30(35(52)39-21(4)32(49)41-25(36(53)54)14-15-29(46)47)43-34(51)27(17-23-10-12-24(44)13-11-23)40-28(45)18-38-33(50)26(42-31(48)20(3)37)16-22-8-6-5-7-9-22/h5-13,19-21,25-27,30,44H,14-18,37H2,1-4H3,(H,38,50)(H,39,52)(H,40,45)(H,41,49)(H,42,48)(H,43,51)(H,46,47)(H,53,54)/t20-,21-,25-,26-,27-,30-/m0/s1

InChIKey: IAVSKDBTQJRRHT-XIGFDZQESA-N


HMG-CoA reductase (EC 1.1.1.34) is involved in cholesterol biosynthesis.


Database reference: