BIOPEP-UWM: Report

ID 9588
Name HMG-CoA reductase inhibitor
sequence
SFGYVAE
Function:
Inhibitor of HMG-CoA reductase (EC 1.1.1.34)
 
Number of residues
7
Activity code
HMGi
Activity :
HMG-CoA reductase inhibitor
Chemical mass 771.8120 Monoisotopic mass 771.3427
IC50 :
0.03 µM


Bibliographic data:
Authors
Pak V. V., Koo M., Kwon D. Y., Yun L.
Title
Design of a highly potent inhibitory peptide acting as a competitive inhibitor of HMG-CoA reductase. Amino Acids, 43, 2015-2025, 2012
Year Source
2012 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: N[C@@]([H])(CO)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)O

InChI=1S/C36H49N7O12/c1-19(2)30(35(53)39-20(3)31(49)41-25(36(54)55)13-14-29(47)48)43-34(52)27(16-22-9-11-23(45)12-10-22)40-28(46)17-38-33(51)26(42-32(50)24(37)18-44)15-21-7-5-4-6-8-21/h4-12,19-20,24-27,30,44-45H,13-18,37H2,1-3H3,(H,38,51)(H,39,53)(H,40,46)(H,41,49)(H,42,50)(H,43,52)(H,47,48)(H,54,55)/t20-,24-,25-,26-,27-,30-/m0/s1

InChIKey: QROJWDYAIIQLPC-UOLJLTGZSA-N


HMG-CoA reductase (EC 1.1.1.34) is involved in cholesterol biosynthesis.


Database reference: