BIOPEP-UWM: Report

ID 9591
Name HMG-CoA reductase inhibitor
sequence
EFGYVAE
Function:
Inhibitor of HMG-CoA reductase (EC 1.1.1.34)
 
Number of residues
7
Activity code
HMGi
Activity :
HMG-CoA reductase inhibitor
Chemical mass 813.8486 Monoisotopic mass 813.3532
IC50 :
0.24 µM


Bibliographic data:
Authors
Pak V. V., Koo M., Kwon D. Y., Yun L.
Title
Design of a highly potent inhibitory peptide acting as a competitive inhibitor of HMG-CoA reductase. Amino Acids, 43, 2015-2025, 2012
Year Source
2012 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)O

InChI=1S/C38H51N7O13/c1-20(2)32(37(56)41-21(3)33(52)43-26(38(57)58)14-16-31(50)51)45-36(55)28(18-23-9-11-24(46)12-10-23)42-29(47)19-40-35(54)27(17-22-7-5-4-6-8-22)44-34(53)25(39)13-15-30(48)49/h4-12,20-21,25-28,32,46H,13-19,39H2,1-3H3,(H,40,54)(H,41,56)(H,42,47)(H,43,52)(H,44,53)(H,45,55)(H,48,49)(H,50,51)(H,57,58)/t21-,25-,26-,27-,28-,32-/m0/s1

InChIKey: HEYCBEGSWIGRRU-UFGRPBDVSA-N


HMG-CoA reductase (EC 1.1.1.34) is involved in cholesterol biosynthesis.


Database reference: