BIOPEP-UWM: Report

ID 9605
Name HMG-CoA reductase inhibitor
sequence
LPYP
Function:
Inhibitor of HMG-CoA reductase (EC 1.1.1.34)
 
Number of residues
4
Activity code
HMGi
Activity :
HMG-CoA reductase inhibitor
Chemical mass 488.5751 Monoisotopic mass 488.2626
IC50 :
484.00 µM


Bibliographic data:
Authors
Kwon D. Y., Oh S. W., Lee J. S., Yang H. J., Lee S. H., Lee J. H., Lee Y. B., Sohn H. S.
Title
Amino acid substitution of hypocholesterolemic peptides originated from glycinin hydrolyzate. Food Sci. Biotechnol., 11, 55–61, 2002
Year Source
2002 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1[C@@]([H])(CCC1)C(=O)O

InChI=1S/C25H36N4O6/c1-15(2)13-18(26)23(32)28-11-3-5-20(28)22(31)27-19(14-16-7-9-17(30)10-8-16)24(33)29-12-4-6-21(29)25(34)35/h7-10,15,18-21,30H,3-6,11-14,26H2,1-2H3,(H,27,31)(H,34,35)/t18-,19-,20-,21-/m0/s1

InChIKey: NRJZAOVJHXKFRI-TUFLPTIASA-N


HMG-CoA reductase (EC 1.1.1.34) is involved in cholesterol biosynthesis.


Database reference:
BindingDB: ID 50226159

BRENDA: Ligand LPYP

ChEMBL: ID CHEMBL412060

ChemSpider: ID 23319380

EPA CompTox: ID DTXSID90659167

EPA DSSTox: ID DTXCID00609916

J-GLOBAL: ID 201707003233025250

Nikkaji: ID J3.595.388D

PubChem: CID 44451976