BIOPEP-UWM: Report

ID 9616
Name HMG-CoA reductase inhibitor
sequence
FGYVAE
Function:
Inhibitor of HMG-CoA reductase (EC 1.1.1.34)
 
Number of residues
6
Activity code
HMGi
Activity :
HMG-CoA reductase inhibitor
Chemical mass 684.7349 Monoisotopic mass 684.3108
IC50 :
0.40 µM


Bibliographic data:
Authors
Pak V. V., Koo M., Kim M. J., Yang H. J., Yun L., Kwon D. Y.
Title
Modeling an active conformation for linear peptides and design of a competitive inhibitor for HMG-CoA reductase. J. Mol. Recognit., 21, 224–232, 2008
Year Source
2008 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: N[C@@]([H])(Cc1ccccc1)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)O

InChI=1S/C33H44N6O10/c1-18(2)28(32(47)36-19(3)29(44)38-24(33(48)49)13-14-27(42)43)39-31(46)25(16-21-9-11-22(40)12-10-21)37-26(41)17-35-30(45)23(34)15-20-7-5-4-6-8-20/h4-12,18-19,23-25,28,40H,13-17,34H2,1-3H3,(H,35,45)(H,36,47)(H,37,41)(H,38,44)(H,39,46)(H,42,43)(H,48,49)/t19-,23-,24-,25-,28-/m0/s1

InChIKey: PKVDOWYZGZDBDE-JGSJVDHVSA-N


HMG-CoA reductase (EC 1.1.1.34) is involved in cholesterol biosynthesis.


Database reference: