BIOPEP-UWM: Report

ID 9618
Name HMG-CoA reductase inhibitor
sequence
GGGGYVAE
Function:
Inhibitor of HMG-CoA reductase (EC 1.1.1.34)
 
Number of residues
8
Activity code
HMGi
Activity :
HMG-CoA reductase inhibitor
Chemical mass 708.7150 Monoisotopic mass 708.3068
IC50 :
760.70 µM


Bibliographic data:
Authors
Pak V. V., Koo M., Kim M. J., Yang H. J., Yun L., Kwon D. Y.
Title
Modeling an active conformation for linear peptides and design of a competitive inhibitor for HMG-CoA reductase. J. Mol. Recognit., 21, 224–232, 2008
Year Source
2008 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: NCC(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)O

InChI=1S/C30H44N8O12/c1-15(2)26(29(48)35-16(3)27(46)37-19(30(49)50)8-9-25(44)45)38-28(47)20(10-17-4-6-18(39)7-5-17)36-24(43)14-34-23(42)13-33-22(41)12-32-21(40)11-31/h4-7,15-16,19-20,26,39H,8-14,31H2,1-3H3,(H,32,40)(H,33,41)(H,34,42)(H,35,48)(H,36,43)(H,37,46)(H,38,47)(H,44,45)(H,49,50)/t16-,19-,20-,26-/m0/s1

InChIKey: VEGJJLYVSSPVHH-CPNZKCELSA-N


HMG-CoA reductase (EC 1.1.1.34) is involved in cholesterol biosynthesis.


Database reference: