BIOPEP-UWM: Report

ID 9682
Name ACE inhibitor
sequence
LPYP
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
4
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 488.5751 Monoisotopic mass 488.2626
IC50 :
5.00 µM


Bibliographic data:
Authors
Dellafiora L., Pugliese R., Bollati C., Gelain F., Galaverna G., Arnoldi A., Lammi C.
Title
"Bottom-Up" strategy for the identification of novel soybean peptides with angiotensin-converting enzyme inhibitory activity. J. Agric. Food Chem., 68, 2082-2090, 2020
Year Source
2020 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1[C@@]([H])(CCC1)C(=O)O

InChI=1S/C25H36N4O6/c1-15(2)13-18(26)23(32)28-11-3-5-20(28)22(31)27-19(14-16-7-9-17(30)10-8-16)24(33)29-12-4-6-21(29)25(34)35/h7-10,15,18-21,30H,3-6,11-14,26H2,1-2H3,(H,27,31)(H,34,35)/t18-,19-,20-,21-/m0/s1

InChIKey: NRJZAOVJHXKFRI-TUFLPTIASA-N


Inhibitor of HMG-CoA reductase (EC 1.1.1.34) according to the BindingDB database; the BIOPEP-UWM database of bioactive peptides (ID 9605); the BRENDA database; the ChEMBL database


Database reference:
BindingDB: ID 50226159

BIOPEP-UWM database of bioactive peptides: ID 9605

BRENDA: Ligand LPYP

ChEMBL: ID CHEMBL412060

ChemSpider: ID 23319380

EPA CompTox: ID DTXSID90659167

EPA DSSTox: ID DTXCID00609916

J-GLOBAL: ID 201707003233025250

Nikkaji: ID J3.595.388D

PubChem: CID 44451976