BIOPEP-UWM: Report

ID 9710
Name PEP inhibitor
sequence
CLVAVALARPKHPIKHQGLP
Function:
Inhibitor of prolyl oligopeptidase (EC 3.4.21.26) (MEROPS ID: S09.001)
 
Number of residues
20
Activity code
am
Activity :
antiamnestic
Chemical mass 2148.6139 Monoisotopic mass 2147.2477
IC50 :
265.60 µM


Bibliographic data:
Authors
Hsieh C. H., Wang T. Y., Hung C. C., Hsieh Y. L., Hsu, K. C.
Title
Isolation of prolyl endopeptidase inhibitory peptides from a sodium caseinate hydrolysate. Food & Function, 7(1), 565-573, 2016
Year Source
2016 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=C[N]([H])C=N2)C(=O)N3[C@@H](CCC3)C(=O)N[C@@H]([C@H](CC)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC4=C[N]([H])C=N4)C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N5[C@@H](CCC5)C(=O)O

InChI=1S/C98H166N30O22S/c1-16-55(12)78(93(145)117-63(26-18-20-34-100)84(136)121-68(42-59-44-105-48-109-59)87(139)115-64(31-32-74(102)129)83(135)108-46-75(130)114-69(41-52(6)7)95(147)128-38-24-30-73(128)97(149)150)125-90(142)72-29-23-37-127(72)96(148)70(43-60-45-106-49-110-60)122-85(137)62(25-17-19-33-99)116-89(141)71-28-22-36-126(71)94(146)65(27-21-35-107-98(103)104)118-79(131)56(13)111-86(138)66(39-50(2)3)119-80(132)57(14)112-91(143)76(53(8)9)123-81(133)58(15)113-92(144)77(54(10)11)124-88(140)67(40-51(4)5)120-82(134)61(101)47-151/h44-45,48-58,61-73,76-78,151H,16-43,46-47,99-101H2,1-15H3,(H2,102,129)(H,105,109)(H,106,110)(H,108,135)(H,111,138)(H,112,143)(H,113,144)(H,114,130)(H,115,139)(H,116,141)(H,117,145)(H,118,131)(H,119,132)(H,120,134)(H,121,136)(H,122,137)(H,123,133)(H,124,140)(H,125,142)(H,149,150)(H4,103,104,107)/t55-,56-,57-,58-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,76-,77-,78-/m0/s1


InChIKey: HBHBOYYZTDZSFT-MJAFTTMSSA-N


Database reference: