BIOPEP-UWM: Report

ID 9800
Name Cyclooxygenase-2 inhibitor
sequence
EQGFLPGPEESGR
Function:
Inhibitor of cyclooxygenase-2 (EC 1.14.99.1)
 
Number of residues
13
Activity code
cox2
Activity :
cyclooxygenase-2 inhibitor
Chemical mass 1402.4616 Monoisotopic mass 1401.6503
IC50 :
3.07 µM


Bibliographic data:
Authors
Złotek U., Jakubczyk A., Rybczyńska-Tkaczyk K., Ćwiek P., Baraniak B., Lewicki S.
Title
Characteristics of new peptides GQLGEHGGAGMG, GEHGGAGMGGGQFQPV, EQGFLPGPEESGR, RLARAGLAQ, YGNPVGGVGH, and GNPVGGVGHGTTGT as inhibitors of enzymes involved in metabolic syndrome and antimicrobial potential. Molecules, 25, 2492, 2020
Year Source
2020 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)NCC(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O

InChI=1S/C60H91N17O22/c1-31(2)25-39(74-55(94)38(26-32-9-4-3-5-10-32)70-45(81)28-66-51(90)34(15-18-43(62)79)71-50(89)33(61)14-19-47(83)84)58(97)77-24-8-12-41(77)56(95)68-29-46(82)76-23-7-13-42(76)57(96)73-36(17-21-49(87)88)53(92)72-35(16-20-48(85)86)54(93)75-40(30-78)52(91)67-27-44(80)69-37(59(98)99)11-6-22-65-60(63)64/h3-5,9-10,31,33-42,78H,6-8,11-30,61H2,1-2H3,(H2,62,79)(H,66,90)(H,67,91)(H,68,95)(H,69,80)(H,70,81)(H,71,89)(H,72,92)(H,73,96)(H,74,94)(H,75,93)(H,83,84)(H,85,86)(H,87,88)(H,98,99)(H4,63,64,65)/t33-,34-,35-,36-,37-,38-,39-,40-,41-,42-/m0/s1

InChIKey=CHJAORMWSLOKQH-NUDUWCFGSA-N


Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the BIOPEP-UWM database of bioactive peptides (ID 9795)
Inhibitor of Alpha-amylase (EC 3.2.1.1) according to the BIOPEP-UWM database of bioactive peptides (ID 9796)
Inhibitor of pancreatic lipase according to the BIOPEP-UWM database of bioactive peptides (ID 9797)
Inhibitor of lipoxygenase (LOX) according to the BIOPEP-UWM database of bioactive peptides (ID 9798)
Inhibitor of cyclooxygenase-1 (EC 1.14.99.1) (COX 1) according to the BIOPEP-UWM database of bioactive peptides (ID 9799)


Database reference:
BIOPEP-UWM database of bioactive peptides: ID 9795; 9796; 9797; 9798; 9799