BIOPEP-UWM: Report

ID 9918
Name Calpain 1 inhibitor
sequence
VF
Function:
Inhibitor of of calpain 1 (EC 3.4.22.52) (MEROPS ID: C02.001)
 
Number of residues
2
Activity code
cal1
Activity :
calpain 1 inhibitor
Chemical mass 264.3194 Monoisotopic mass 264.1469
IC50 :
0.00 µM


Bibliographic data:
Authors
Iqbal M., Messina P. A., Freed B., Das M., Chatterjee S., Tripathy R., Tao M., Josef K. A., Dembofsky B., Dunn D., Griffith E., Siman R., Senadhi S. E., Biazzo W., Bozyczko-Coyne D., Meyer S. L., Ator M. A., Bihovsky R.
Title
Subsite requirements for peptide aldehyde inhibitors of human calpain I. Bioorg. Med. Chem. Lett., 7, 539-544, 1997
Year Source
1997 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@H](C(=O)N[C@H](C(=O)O)Cc1ccccc1)C(C)C

InChI=1S/C14H20N2O3/c1-9(2)12(15)13(17)16-11(14(18)19)8-10-6-4-3-5-7-10/h3-7,9,11-12H,8,15H2,1-2H3,(H,16,17)(H,18,19)/t11-,12-/m0/s1

InChIKey: GJNDXQBALKCYSZ-RYUDHWBXSA-N


Peptide found in hydrolysate of sardine muscle proteins.
Matsufuji H., Matsui T., Seki E., Osajima K., Nakashima M., Osajima Y., 1994, Angiotensin I-converting enzyme inhibitory peptides in an alkaline proteinase hydrolysate derived from sardine muscle. Biosci. Biotech. Biochem., 58, 2244-2245

Peptide found in amaranth protein hydrolysate.
Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111


Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database; the BIOPEP-UWM database of bioactive peptides (ID 3384); the ChEMBL database; the EROP-Moscow database (ID E01330); the PubChem database
Inhibitor of Calpain 1 (EC 3.4.22.52) (MEROPS ID: C02.001) according to the ChEMBL database; the PubChem database
Inhibitor of Tripeptidyl peptidase 2 (EC 3.4.14.10) (MEROPS ID S08.090) according to the BRENDA database; the ChEMBL database; the PubChem database
Inhibitor of Neprilysin-2 (EC 3.4.24.B14) (MEROPS ID: M13.008) according to the BRENDA database
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8917)

Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 51)


Database reference:
AHTPDB: ID 1099; 1196; 1364; 1499; 1905; 1955; 2585; 2777; 3097; 3121; 3156; 3198; 3341; 3786; 4037; 4120; 4211; 4445; 4492; 4667; 4953; 5176; 5456; 5627; 6145; 6177; 6262; 6368; 6878

BindingDB: ID 50142287

BioPepDB: ID biopep01357

BIOPEP-UWM database of bioactive peptides: ID 3384; 8917

BIOPEP-UWM database of sensory peptides and amino acids: ID 51

BRENDA: Ligand Val-Phe

ChEBI: ID 75016

ChEMBL: ID CHEMBL8486

ChemIdplus: ID 75946-40-6

ChemSpider ID: 5361223

EROP-Moscow: ID E01330; E03690

FeptideDB: ID 3384; 8917

FooDB: ID FDB112136

HMDB: ID HMDB0029134

J-GLOBAL: ID 200907084614108273

Metabolights: ID MTBLC75016

Nikkaji: ID J149.638G

PubChem: ID 6993120

SATPdb: ID satpdb14826

SureChEMBL: ID SCHEMBL7335375

ZINC: ID ZINC000001605725