BIOPEP-UWM: Report

ID 12
Name bitter peptide
sequence
PR
Function:
(Rcaf) 0.33
 
Number of residues
2
Activity code
bi
Activity :
bitter
Chemical mass 271.3153 Monoisotopic mass 271.1640
EC50 :
0.00 µM


Bibliographic data:
Authors
Otagiri K., Nosho Y., Shinoda I., Fukui H., Okai H.
Title
Studies on a model bitter peptides including arginine, proline and phenylalanine residues. I. Bitter taste of di- and tripeptides and bitterness increase of the model peptides by extension of the peptide chain. Agric. Biol. Chem., 49, 1019-1026, 1985
Year Source
1985 Journal


Additional information:
BIOPEP-UWM database of sensory peptides and amino acids

SMILES: C1C[C@H](NC1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O

InChI=1S/C11H21N5O3/c12-11(13)15-6-2-4-8(10(18)19)16-9(17)7-3-1-5-14-7/h7-8,14H,1-6H2,(H,16,17)(H,18,19)(H4,12,13,15)/t7-,8-/m0/s1

InChIKey: HMNSRTLZAJHSIK-YUMQZZPRSA-N


Another reference concerning bitterness:
Ueno Y., Sakurai T., Okada S., Abe K., Misaka T., 2011, Human bitter taste receptors hTAS2R8 and hTAS2R39 with differential functions to recognize bitter peptides. Biosci. Biotech. Biochem., 75, 1188-1190


Inhibitor of angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database; the BIOPEP-UWM database of bioactive peptides (ID 3537), the EROP-Moscow database
Inhibitor of the dipeptidyl-peptidase III (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BIOPEP-UWM database of bioactive peptides (ID 3537); the BRENDA database

Peptide found in sake lee

Saito Y., Wanezaki K., Kawato A., Imayasu S., 1994, Structure and activity of angiotensin I converting enzyme inhibitory peptides from sake and sake lees. Biosci. Biotech. Biochem., 58, 1767-1771;

Peptide found in amaranth protein hydrolysate.

Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111


Database reference:
ACToR: ID 2418-74-8

AHTPDB: ID 1179; 1374; 3206; 3526; 4011; 4104; 5431; 5618; 6454

BindingDB: ID 50169180

BioPepDB: ID biopep01094

BIOPEP-UWM database of bioactive peptides: ID 3537; 9489

BitterDB: ID 837

BRENDA: Ligand Pro-Arg

CHEBI: ID 73645

ChEMBL: ID CHEMBL190549

ChemIdPlus: ID 2418-74-8

ChemSpider: ID 133096

CTD: ID 2418-74-8

eChemPortal: ID 2418-74-8

EPA CompTox: ID DTXSID30178887

EPA DSSTox: ID DTXCID90101378

EROP-Moscow: ID E09262

J-GLOBAL: ID 200907076180042977

Metabolomics Workbench: ID 78937

Nikkaji: ID J1.353.238I

PubChem: CID 151004

SATPdb: ID satpdb16956

ZINC: ID ZINC04899789