BIOPEP-UWM: Report

ID 160
Name bitter peptide
sequence
LL
Function:
(Rcaf) 0.4
 
Number of residues
2
Activity code
bi
Activity :
bitter
Chemical mass 244.3296 Monoisotopic mass 244.1781
EC50 :
0.00 µM


Bibliographic data:
Authors
Ishibashi N., Kouge K., Shinoda I., Kanhisa H., Okai H.
Title
A mechanism for bitter taste sensibility in peptides. Agric. Biol. Chem., 52, 819-827, 1988
Year Source
1988 Journal


Additional information:
BIOPEP-UWM database of sensory peptides and amino acids


SMILES: N[C@H](C(=O)N[C@H](C(=O)O)CC(C)C)CC(C)C

InChI=1S/C12H24N2O3/c1-7(2)5-9(13)11(15)14-10(12(16)17)6-8(3)4/h7-10H,5-6,13H2,1-4H3,(H,14,15)(H,16,17)/t9-,10-/m0/s1

InChIKey: LCPYQJIKPJDLLB-UWVGGRQHSA-N


Another references concerning taste:

Asao M., Iwamura H., Akamatsu M., Fujita T., 1987, Quantitative structure-activity relationships of the bitter thresholds of amino acids, peptides, and their derivatives. J. Med. Chem., 30, 1873-1879

Collantes E. R., Dunn W. J., 1995, Amino acid side chain descriptors for quantitative structure-activity relationship studies of peptide analogues. J. Med. Chem., 38, 2705-2713


Peptide found in whey protein hydrolysate:

Morifuji M., Koga J., Kawanaka K., Higuchi M., 2009, Branched-chain amino acid-containing dipeptides, identified from whey protein hydrolysates, stimulate glucose uptake in L6 myotubes and isolated skeletal muscles. J. Nutr. Sci. Vitaminol., 55, 81-86


Inhibitor of Cytosol alanyl aminopeptidase (EC 3.4.11.14) (MEROPS ID: M01.010) according to the BRENDA database
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 3182); the BRENDA database; the EROP-Moscow database
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database
Inhibitor of Lactocepin (EC 3.4.21.96) (MEROP ID: S08.019) according to the BRENDA database
Glucose uptake stimulating peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8326)
Inhibitor of citrulline uptake in yeasts according to the ChEMBL database; the PubChem database


Database reference:
AHTPDB: ID 3853; 5405

BindingDB: ID 50188496

BIOPEP-UWM database of bioactive peptides: ID 3182; 8326

BRENDA: Ligand Leu-Leu

ChEBI: ID 73531

ChEMBL: ID 54933

ChemIDplus: ID 003303319

ChemSpider: ID 69263

EPA DSSTox: ID DTXSID00186696

EROP-Moscow: ID E06688

FeptideDB: ID 3182; 8326

FooDB: ID FDB111960

HMDB: ID HMDB0028933

J-GLOBAL: ID 200907023863170060

KEGG: ID C11332

KNApSAcK: ID C00038887

MeSH: term L-leucyl-L-leucine

MetaCyc: Compound L-leucyl-L-leucine

Nikkaji: ID J80.685D

PlantPepDB: ID PPepDB_3428

PubChem: CID 76807

SAPdb: ID 1636; 1637

SATPdb: ID satpdb13702

SureChEMBL: ID SCHEMBL235250

ZINC: ID ZINC01532219