BIOPEP-UWM: Report

ID 194
Name bitter peptide
sequence
IL
Function:
(Rcaf) 0.67
 
Number of residues
2
Activity code
bi
Activity :
bitter
Chemical mass 244.3296 Monoisotopic mass 244.1781
EC50 :
0.00 µM


Bibliographic data:
Authors
Ishibashi N., Arita Y., Kanehisa H., Kouge K., Okai H., Fukui S.
Title
Bitterness of leucine-containing peptides. Agric. Biol. Chem., 51, 2389-2394, 1987
Year Source
1987 Journal


Additional information:

BIOPEP-UWM database of sensory peptides and amino acids


SMILES: N[C@H](C(=O)N[C@H](C(=O)O)CC(C)C)[C@H](CC)C

InChI=1S/C12H24N2O3/c1-5-8(4)10(13)11(15)14-9(12(16)17)6-7(2)3/h7-10H,5-6,13H2,1-4H3,(H,14,15)(H,16,17)/t8-,9-,10-/m0/s1

InChIKey: JWBXCSQZLLIOCI-GUBZILKMSA-N


Another references concerning bitterness:

Asao M., Iwamura H., Akamatsu M., Fujita T., 1987, Quantitative structure-activity relationships of the bitter thresholds of amino acids, peptides, and their derivatives. J. Med. Chem., 30, 1873-1879

Collantes E. R., Dunn W. J., 1995, Amino acid side chain descriptors for quantitative structure-activity relationship studies of peptide analogues. J. Med. Chem., 38, 2705-2713


Peptide found in whey protein hydrolysate:

Morifuji M., Koga J., Kawanaka K., Higuchi M., 2009, Branched-chain amino acid-containing dipeptides, identified from whey protein hydrolysates, stimulate glucose uptake in L6 myotubes and isolated skeletal muscles. J. Nutr. Sci. Vitaminol., 55, 81-86


Stimulator of glucose uptake according to the BIOPEP-UWM database of bioactive peptides (ID 8323); EROP-Moscow database
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8802)
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database; the BIOPEP-UWM database of bioactive peptides (ID 9079)
Antinociceptive neuropeptide according to the ChEMBL database; the PubChem database
Inhibitor of citrulline uptake in yeasts according to the ChEMBL database; the PubChem database


Database reference:
AHTPDB: ID 1438; 3860; 5410

BindingDB: ID 50282190

BioPepDB: ID biopep00542

BIOPEP-UWM database of bioactive peptides: ID 8323; 8802; 9079

BRENDA: Ligand Ile-Ieu

ChEBI: ID 74072

ChEMBL: ID CHEMBL48832

ChemSpider: ID 5382050

EPA CompTox: ID DTXSID00427071

EPA DSSTox: ID DTXCID40377905

EROP-Moscow: ID E10605

J-GLOBAL: ID 200907038945135805

Metabolights: ID MTBLC74072

Nikkaji: ID J1.013.425K

PubChem: ID 7019083

SATPdb: ID satpdb25152

SureChEMBL: ID SCHEMBL3010040

ZINC: ID ZINC02556613