BIOPEP-UWM: Report

ID 240
Name Salty peptide
sequence
DD

Function:
Salty taste; threshold 4.79 mM
 
Number of residues
2
Activity code
sal
Activity :
salty
Chemical mass 248.1896 Monoisotopic mass 248.0641
EC50 :
0.00 µM



Bibliographic data:
Authors
Tamura M., Nakatsuka T., Tada M., Kawasaki Y., Kikuchi E., Okai H.
Title
The relationship between taste and primary structure of "Delicious Peptide" (Lys-Gly-Asp-Glu-Glu-Ser-Leu-Ala) from beef soup. Agric. Biol. Chem., 53, 319-325, 1989
Year Source
1989 Journal



Additional information:
BIOPEP database of sensory peptides and amino acids


SMILES: N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)O

InChI=1S/C8H12N2O7/c9-3(1-5(11)12)7(15)10-4(8(16)17)2-6(13)14/h3-4H,1-2,9H2,(H,10,15)(H,11,12)(H,13,14)(H,16,17)/t3-,4-/m0/s1

InChIKey: FRYULLIZUDQONW-IMJSIDKUSA-N


Salty/umami at pH = 6;

Kuramitsu R., Takahashi M., Tahara K., Nakamura K., Okai H., 1996, Tastes produced by peptides containing ionic groups and by related compounds. Biosci., Biotech., Biochem., 60, 1637-1642

Sour peptide according to BIOPEP database of sensory peptides and amino acids (ID 238);
Umami peptide according to BIOPEP database of sensory peptides and amino acids (ID 239)

Reported also as tasteless:
van den Oord A. H. A., van Wassenaar P. D. 1997, Umami peptides: assessment of their alleged taste properties. Z. Lebensm. Unters. Forsch., 205, 125-130

Inhibitor of Glutamate carboxypeptidase II (EC 3.4.17.21) (MEROPS ID: M28.010) according to BRENDA database; ChEMBL database
Inhibitor of HIV-1 retropepsin (EC 3.4.23.16) (MEROPS ID: A02.001) according to BRENDA database
Activator of Carbonic anhydrase (EC 4.2.1.1) according to ChEMBL database; PubChem database



Database reference:
BindingDB: ID 50169127

BIOPEP database of sensory peptides and amino acids: ID 238; 239

BRENDA: Ligand Asp-Asp

ChEBI: ID 73446

ChEMBL: ID CHEMBL17171

ChemSpider: ID 414197

PubChem: ID 471583

ZINC: ID ZINC01575288