BIOPEP-UWM: Report

ID 31
Name bitter peptide
sequence
YG
Function:
(Rcaf) 0.33
 
Number of residues
2
Activity code
bi
Activity :
bitter
Chemical mass 238.2393 Monoisotopic mass 238.0950
EC50 :
0.00 µM


Bibliographic data:
Authors
Ishibashi N., Sadamori K., Yamamoto O., Kanehisa H., Kouge K., Kikuchi E., Okai H., Fukui S.
Title
Bitterness of phenylalanine- and tyrosine-containing peptides. Agric. Biol. Chem., 51, 3309-3313, 1987
Year Source
1987 Journal


Additional information:

BIOPEP-UWM database of sensory peptides and amino acids


SMILES: c1cc(ccc1C[C@@H](C(=O)NCC(=O)O)N)O

InChI=1S/C11H14N2O4/c12-9(11(17)13-6-10(15)16)5-7-1-3-8(14)4-2-7/h1-4,9,14H,5-6,12H2,(H,13,17)(H,15,16)/t9-/m0/s1

InChIKey: HPYDSVWYXXKHRD-VIFPVBQESA-N


Peptide found in cod protein hydrolysates:

Geirsdóttir M., 2009, Isolation, purification and investigation of peptides from fish proteins with blood pressure decreasing properties. Report from the project funded by the AVS research fund under the Ministry of Fisheries in Iceland (project no. R-047-07). Matís Report 36-09, Matís, Reykjavik, Iceland, http://www.avs.is/media/avs/36-09_skyrsla_einangrun_peptida.pdf

Found in amaranth (Amarantus hypochondriacus) proteins:

Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111


Inhibitor of Angiotensin-converting enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database, the BindingDB database; the BIOPEP-UWM database of bioactive peptides (ID 3553), the ChEMBL database
Immunomodulating peptide according to the BIOPEP-UWM database of bioactive peptides (ID 2882)
Inhibitor of nitrogen uptake in yeasts according to the ChEMBL database
Inhibitor of Dipeptidyl peptidase III (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BIOPEP-UWM database of bioactive peptides (ID 9508); the BRENDA database
Inhibitor of Dipeptidyl peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8936)
Inhibitor of Tubulin-tyrosine ligase (EC 6.3.2.25) according to the BRENDA database


Database reference:
AHTPDB: ID 1206; 1327; 1351; 1387; 1480; 2998; 3210; 3303; 3548; 3598; 3803; 4053; 4423; 4509; 4656; 5428; 5635; 6467

BindingDB: ID 50188519

BioPepDB: ID biopep01556

BIOPEP-UWM database of bioactive peptides: ID 2882; 3553; 8936; 9508

BRENDA: Ligand Tyr-Gly

ChEBI: ID 74990

ChEMBL: ID CHEMBL89956

ChemSpider: ID 5384746

EROP-Moscow: ID E09271

HMDB: ID HMDB29105

J-GLOBAL: ID 200907017245435665

Metabolights: ID MTBLC74990

Nikkaji: ID J258.522G

PubChem: ID 7021853

SATPdb: ID satpdb13810

SureChEMBL: ID SCHEMBL4407092

ZINC: ID ZINC000002575475