BIOPEP-UWM: Report

ID 342
Name Bitter peptide
sequence
WW
Function:
Bitter taste
 
Number of residues
2
Activity code
bi
Activity :
bitter
Chemical mass 390.4342 Monoisotopic mass 390.1687
EC50 :
0.00 µM


Bibliographic data:
Authors
Asao M., Iwamura H., Akamatsu M., Fujita T.
Title
Quantitative structure-activity relationships of the bitter thresholds of amino acids, peptides, and their derivatives. J. Med. Chem., 30, 1873-1879
Year Source
1987 Journal


Additional information:
BIOPEP database of sensory peptides and amino acids


SMILES: N[C@@H](Cc1c2ccccc2[nH]c1)C(=O)N[C@@H](Cc1c2ccccc2[nH]c1)C(=O)O

InChI=1S/C22H22N4O3/c23-17(9-13-11-24-18-7-3-1-5-15(13)18)21(27)26-20(22(28)29)10-14-12-25-19-8-4-2-6-16(14)19/h1-8,11-12,17,20,24-25H,9-10,23H2,(H,26,27)(H,28,29)/t17-,20-/m0/s1

InChIKey: NQIHMZLGCZNZBN-PXNSSMCTSA-N


Another reference concerning bitterness:
Kohl S., Behrens M., Dunkel A., Hofmann T., Meyerhof W., 2013, Amino acids and peptides activate at least five members of the human bitter taste receptor family. J. Agric. Food Chem., 61, 53-60


Inhibitor of hemoglobin S gelation according to ChEMBL database, PubChem database
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to BIOPEP database of bioactive peptides; ChEMBL database; EROP-Moscow database, PubChem database


Database reference:

BindingDB: ID 50188479

BIOPEP database of bioactive peptides: ID 8686

BitterDB: ID 832

BRENDA: Ligand Trp-Trp

ChEBI: ID 74876

ChEMBL: ID CHEMBL286852

ChemIDplus: ID 020696600

ChemSpider: ID 79994

EROP-Moscow: ID E10612

PubChem: ID 88656

ZINC: ID ZINC01557161